AI Article Synopsis
- - The study investigates how inflammation, represented by neutrophil-to-lymphocyte ratio (NLR) and neutrophil count (PNN), impacts survival outcomes in patients with localized bladder cancer undergoing chemoradiation.
- - Analyzed data from 194 patients showed that those with high NLR (above 2.6) and elevated PNN (above 4000/mm) experienced significantly lower overall survival (OS) and progression-free survival (PFS).
- - While high PNN was a strong indicator of poor OS and PFS outcomes, NLR did not prove to be an independent prognostic factor in this analysis.
Article Abstract
Background: The role of inflammation in the development and prognosis of bladder cancer (BC) is now established. We evaluated the significance of neutrophil-to-lymphocyte ratio (NLR) and neutrophil count (PNN) in patients with localized BC treated with chemoradiation.
Methods: Clinical characteristics and baseline biological data were retrospectively collected. We tested the association between NLR, PNN, and overall survival (OS) and progression-free survival (PFS).
Results: One hundred and ninety-four patients were included. Median PNN was 4000.0/mm [1500.0-16,858.0] and median NLR was 2.6 [0.6-19.2]. In patients with NLR > 2.6, median OS and PFS were lower (OS: 25.5 vs. 58.4 months, = 0.02; PFS: 14.1 vs. 26.7 months, = 0.07). Patients with PNN > 4000/mm had significantly lower OS (21.8 vs. 70.1 months, < 0.001) and PFS (13.7 vs. 38.8 months, < 0.001). Contrary to NLR, PNN > 4000/mm was associated with shorter OS and PFS in multivariate analysis.
Conclusions: Elevated PNN at baseline was associated with worse OS and PFS. NLR was not an independent prognostic factor.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047214 | PMC |
| http://dx.doi.org/10.3390/cancers15061886 | DOI Listing |
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