Many disease-causing mutations can have mild or no effects in some people. This incomplete phenotype penetrance phenomenon is still poorly understood, but model animal studies now show that it is stochastic, with the outcome akin to flipping a coin. These findings can affect how genetic diseases are understood and treated.
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| http://dx.doi.org/10.1016/j.cub.2023.02.052 | DOI Listing |
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