AI Article Synopsis
- SARS-CoV-2 is responsible for the COVID-19 pandemic and is evolving through genetic mutations, presenting ongoing public health challenges.
- A low concentration of a specific monoclonal antibody targeting angiotensin-converting enzyme 2 can unexpectedly enhance the infection and growth of SARS-CoV-2 in cell cultures.
- This enhancement allows for better quantification of infectious titers for different variants, especially the newer Omicron variants, aiding in vaccine and antiviral drug development.
Article Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) pandemic and continues to pose a threat to global public health through genetic mutation. In this study, we have found that an angiotensin-converting enzyme 2-specific monoclonal antibody at low concentration was able to enhance SARS-CoV-2 infection and growth in cell culture. Strikingly, it promotes SARS-CoV-2 plaque formation, resulting in accurate titration of different SARS-CoV-2 variants, particularly the newly emerged Omicron variants, which otherwise cannot be determined by standard plaque assays. Quantification of infectious titers of the newly emerged variants will facilitate the development and evaluation of vaccines and antiviral drugs against SARS-CoV-2.
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| http://dx.doi.org/10.1002/jmv.28711 | DOI Listing |
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