The intestine is a site of immune cell priming at birth. Therefore, spatial transcriptomes were performed to define how the transcriptomic landscape was spatially organized in the posterior intestine of following infection. In the healthy condition, we identified a previously unappreciated molecular regionalization of the posterior intestine. Following bacterial infection, most immune-related genes were identified in mucosa layer. Moreover, investigation of immune-related genes and genes in immune-related KEGG pathways based on spatial transcriptomes shed light on which sections of these genes are in the posterior intestine. Meanwhile, the high expression of genes related to regeneration also indicated that the posterior intestine was responding to the invasion of pathogens by constantly proliferating new cells. In addition, the increasing microbiota communities indicated that these bacteria maintained posterior intestine integrity and shaped the mucosal immune system. Taken together, spatial transcriptomes and microbiota compositions have significant implications for understanding the immune mechanism that responds to infection in the posterior intestine of , which also provides a theoretical basis for the spatial distribution of immune genes and changes in bacterial flora in other teleosts in the process of resisting pathogens.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944294 | PMC |
| http://dx.doi.org/10.1098/rsob.220302 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Uncomplicated Amyand's hernia in a setting of abdominal wall insufficiency: a case report.
J Med Case Rep
January 2025
Dept. of General Surgery, Fortis Hospital, Sector 62, Noida, UP, 201309, India.
Introduction: Amyand's hernia, an uncommon condition characterized by the presence of the appendix within an inguinal hernial sac (< 1% incidence), poses diagnostic and therapeutic challenges. Often it is an intraoperative finding, with almost no clinical symptoms.
Case Presentation: This is a case of an Indian male in his early 80 years, diagnosed with bilateral direct inguinal hernias, one of which contained a noninflamed appendix.
In Vivo visualization of microplastic degradability and intestinal functional responses in a plastivore insect.
J Hazard Mater
January 2025
School of Energy and Environment and State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon 999077, Hong Kong; Research Centre for the Oceans and Human Health, City University of Hong Kong Shenzhen Research Institute, Shenzhen 518057, China. Electronic address:
The plastivore insect Tenebrio molitor demonstrates significant potential for the rapid biodegradation and bioremediation of micro(nano)plastics. However, real-time visualization of the digestive degradation and removal of microplastics (MPs) during intestinal transit, along with the associated in vivo intestinal functional responses, remains challenging. Here, we developed second near-infrared (NIR-II) window aggregated-induced emission (AIE) MPs of two sizes (29.
View Article and Find Full Text PDFSpondylo-Thoracic Dysplasia: Survival, a Rare Occurrence.
Cureus
December 2024
Pediatric Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND.
Article Synopsis
- Spondylo-thoracic dysplasia (STD) is a rare congenital condition that affects the vertebrae and thoracic area, often leading to serious respiratory issues and a high risk of early death in neonates.
- The text details the case of a one-day-old male newborn with severe respiratory distress and various physical anomalies, including scoliosis and rib deformities, identified through clinical examinations and imaging studies.
- The baby was diagnosed with STD, received conservative management, and survived past the neonatal period, offering insights into this particular variant of the condition.
Laparoscopic Reversal of Roux-en-Y Gastric Bypass with Hand-Sewn Gastro-Gastrostomy and Resection of the Alimentary Limb.
Obes Surg
December 2024
Department of Upper Gastrointestinal and Bariatric Surgery, University Hospitals Sussex (St Richard's Hospital), Chichester, UK.
Introduction: Roux-en-Y gastric bypass (RYGB) reversal might be necessary to alleviate refractory surgical or nutritional complications, such as postprandial hypoglycemia, malnutrition, marginal ulceration, malabsorption, chronic diarrhea, nausea and vomiting, gastro-esophageal reflux disease, chronic pain, or excessive weight loss. The surgical technique of RYGB reversal is not standardized; potential strategies include the following: (1) gastro-gastrostomy: hand-sewn technique, linear stapler, circular stapler; (2) handling of the Roux limb: reconnection or resection (if remaining intestinal length ≥ 4 m).
Case Presentation: We demonstrate the surgical technique of a laparoscopic reversal of RYGB with hand-sewn gastro-gastrostomy and resection of the alimentary limb with the aim of improving the patient's quality of life.
Foundational Image Analyses for Ultrasonographic Screening of Abdominal Aortic Aneurysm.
Ann Vasc Dis
December 2024
Department of Anesthesiology, Kochi Medical School, Nankoku, Kochi, Japan.
With improved surgical outcomes for non-ruptured abdominal aortic aneurysm (AAA), the primary objective has shifted toward the detection of asymptomatic AAA. Since ultrasonographic visualization from the anterior abdominal wall is often obstructed by intestinal gas, utilizing additional bilateral posterior approaches via the retroperitoneal tissue may be beneficial. This study investigates the feasibility of assessment using three approaches through computed tomography (CT) data analyses.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!