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Impacts of genomic alterations on the efficacy of HER2-targeted antibody-drug conjugates in patients with metastatic breast cancer.
J Transl Med
January 2025
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, No.651 Dongfeng East Road, Guangzhou, 510060, People's Republic of China.
Background: HER2-targeted antibody-drug conjugates (ADCs) have revolutionized the treatment landscape of metastatic breast cancer. However, the efficacy of these therapies may be compromised by genomic alterations. Hence, this study aims to identify factors predicting sensitivity to HER2 ADC in metastatic breast cancer.
View Article and Find Full Text PDFOn Your Mark, Get Set, Choose! A Randomized Cross-Over Study Comparing Fixed and Self-Selected Rest Periods in Interval Running Among Professional Female Soccer Players.
Sports Med Open
January 2025
Department of Health Promotion, Faculty of Medical and Health Sciences, School of Public Health, Tel-Aviv University, Tel-Aviv, Israel.
Background: Studies on rest durations during high-intensity interval training (HIIT) often compare fixed and self-selected (SS) rest allocation approaches. Frequently, the rest duration under SS conditions is unlimited, leading to inconsistent total rest durations compared to fixed rest conditions. To address this limitation, we recently compared fixed and SS rest conditions during cycling HIIT sessions, while keeping the total rest duration equivalent.
View Article and Find Full Text PDFAdvances in surgical management of chronic lymphedema: current strategies and future directions.
Med Oncol
January 2025
Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Lymphedema is a chronic condition caused by the accumulation of protein-rich fluid in the interstitial tissue, resulting in edema and a diminished quality of life. When first-line treatments like complete decongestive therapy (CDT) fail, surgical options are considered. These include physiological procedures like lymphaticovenous anastomosis (LVA) and vascularized lymph node transfer (VLNT), which aim to restore lymphatic function, as well as reductive procedures such as liposuction and excisional techniques, which reduce limb volume.
View Article and Find Full Text PDFGeneral Endotracheal Anesthesia vs Total Intravenous Anesthesia for Children Undergoing Low-Risk Cardiac Catheterization.
Pediatr Cardiol
January 2025
Division of Pediatric Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN, 55901, USA.
Historically, children undergoing cardiac catheterization have been managed with general endotracheal anesthesia (GETA). However, recent practice has favored general anesthesia with total intravenous anesthesia (TIVA). This study compares procedural outcomes in the pediatric cardiac catheterization laboratory (PCCL) for children undergoing low-risk cardiac catheterization with GETA vs.
View Article and Find Full Text PDFSurvival and prognostic factors among different types of liposarcomas based on SEER database.
Sci Rep
January 2025
Orthopedics Department, The First Affiliated Hospital of Army Medical University, Chongqing, China.
The aim of this study is to elucidate the disparities in survival and risk factors among different subtypes of liposarcoma, through analysis of epidemiological and prognostic data. The study cohort consisted of 12,822 patients diagnosed with liposarcoma in the United States between 2000 and 2021, whose data were retrieved from the Surveillance, Epidemiology, and End Results (SEER) program. The prognosis for different subtypes of liposarcoma and the associated factors such as age, tumor stage, intervention, gender, tumor grade, location, size, chemotherapy and radiotherapy, were retrieved from the database.
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