AI Article Synopsis
- Neoadjuvant chemotherapy response is linked to patient survival in breast cancer but predicting which patients will respond remains an ongoing research challenge.
- Serum CK18 levels were measured in 52 newly diagnosed breast cancer patients before and after their first cycle of chemotherapy to explore its correlation with clinical outcomes.
- High pre-treatment CK18 levels indicated progressive disease, while significant post-treatment CK18 increases were associated with positive therapy responses, suggesting that CK18 measurements could be useful for predicting tumor response to neoadjuvant chemotherapy.
Article Abstract
Background: Currently, it is well recognized that response to neoadjuvant chemotherapy is an important predictive factor for survival in breast cancer patients. However, it is still an area of research about which patient would respond to the neoadjuvant chemotherapy.
Methods: Serum CK18 levels were measured using ELISA from 52 newly diagnosed breast cancer patients, at presentation and after first cycle of neo-adjuvant chemotherapy. Pre- and post-treatment CK-18 levels were correlated with several clinical and pathological parameters. At the end of neoadjuvant treatment, changes in serum CK18 levels were correlated with tumors' response to therapy.
Results: Significant elevation of pre-chemotherapy CK18 level was observed in patients who had progressive disease compared to those who had complete or partial response to therapy (P=0.006 and P<0.001, respectively). Significantly higher CK18 levels were observed post-chemotherapy in complete and partial responders, in contrast to patients with stable or progressive disease (P=0.012% and P=0.001%, respectively). The percent of change was significantly higher in complete responders compared to patients who had stable or progressive disease (P=0.043% and P=0.045%, respectively).
Conclusion: Our results suggest that patients with increasing CK18 level following chemotherapy are potential responders to their neoadjuvant protocol. Thus, the measurement of serum CK18 early in the treatment course could be a simple, noninvasive way to predict tumor response to neoadjuvant chemotherapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334074 | PMC |
| http://dx.doi.org/10.31557/APJCP.2023.24.3.969 | DOI Listing |
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