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Genetic and Cultural Transmission of Alcohol Use Disorder in Swedish Twin Pedigrees. | LitMetric

Genetic and Cultural Transmission of Alcohol Use Disorder in Swedish Twin Pedigrees.

J Stud Alcohol Drugs

Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.

Published: May 2023

AI Article Synopsis

  • This study explored how genetic and environmental factors contribute to alcohol use disorder (AUD) using data from Swedish national registries, focusing on extended family lineages of twins.* -
  • Researchers analyzed AUD definitions through various records, studying nearly 162,469 individuals across 18,971 family trees, finding that heritability is significant, estimated at 50%-60%, especially higher in men compared to women.* -
  • Results indicate that shared environmental influences also play a vital role, accounting for about 10%-20% of risk, with additional factors contributing to the remaining variance; this highlights the complex nature of AUD's origins.*

Article Abstract

Objective: Using Swedish nationwide registry data, we investigated the contribution of genetic and environmental risk factors to the etiology of alcohol use disorder (AUD) by extended twin pedigree modeling.

Method: AUD was defined using public inpatient, outpatient, prescription, and criminal records. Three-generational pedigrees were selected for index individuals born between 1980 and 1990, obtained from the national twin and genealogical registers, whose parents were twins. Relatives of the twins included in the pedigrees were their parents, siblings, spouses, and children. Genetic structural equation modeling was applied to the population-based data on AUD, using OpenMx, with age used as a covariate.

Results: Analyses including up to 162,469 individuals in 18,971 pedigrees estimated AUD prevalence at 5%-12% in men and 2%-5% in women. Results indicated substantial heritability (about 50%-60%), of which a portion upwards of 5% was attributable to the consequences of assortative mating. Contributions of shared environmental factors to AUD, which represent a mix of within- and cross-generational effects, appeared to be moderate (about 10%-20%). Unique environment accounted for the remaining variance (about 20%-30%). Sex differences in the magnitude of the variance components suggested higher heritability in men and correspondingly higher shared environmental contributions in women.

Conclusions: Using objective registry data, we found that AUD is highly heritable. Furthermore, shared environmental factors contributed significantly to the liability of AUD in both men and women.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364785PMC
http://dx.doi.org/10.15288/jsad.22-00097DOI Listing

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