We, herein, report on the bromocyanation of styrene derivatives with cyanogen bromide in the presence of tris(pentafluorophenyl)borane which functions as a Lewis acid catalyst that can effectively activate cyanogen bromide. This reaction proceeds through a stereospecific -addition. The protocol is operationally simple and provides practical access to β-bromonitriles.
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| http://dx.doi.org/10.1021/acs.orglett.3c00727 | DOI Listing |
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