Obsessive-compulsive symptoms induced by clozapine negatively affect treatment compliance. In some studies, clonazepam was shown to be beneficial in obsessive-compulsive disorder. However, in literature there are case reports of life-threatening complications associated with the combined use of clozapine and benzodiazepines. In this article, the efficacy and safety of the clonazepam augmentation were discussed in two patients who had obsessive-compulsive symptoms induced by clozapine. No life-threatening complications were detected during the follow-up period of more than two years, and the patients benefited dramatically from the addition of clonazepam. In treatment-resistant patients, clonazepam can be used with close monitoring for obsessivecompulsive symptoms associated with atypical antipsychotics. Keywords: Atypical antipsychotics, clonazepam, clozapine, obsessivecompulsive symptoms.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552166 | PMC |
| http://dx.doi.org/10.5080/u27025 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The relation between obsessive-compulsive disorder (OCD) and circadian rhythm disturbance has been increasingly acknowledged in recent years. While prior clinical studies have utilized patients' self-reported sleep behaviors, there is a need to also explore the measurable, biological aspects of circadian rhythms. The current study has two aims: first, to describe the biological circadian rhythms of individuals with OCD seeking intensive residential treatment, including their relationship with self-reported measures of sleep and OCD symptoms; and second, to examine longitudinal associations between biological circadian rhythms and OCD symptom severity during the course of residential treatment.
View Article and Find Full Text PDFAdult Attachment Style, Emotion Regulation and Obsessive-Compulsive Disorder-A Preliminary Cross-Sectional Mediational Investigation of an Attachment-Based Model.
Clin Psychol Psychother
January 2025
Mental Health Services, Capital Region of Denmark, Copenhagen, Denmark.
There is evidence that emotion regulation plays a role in the aetiology and maintenance of OCD, but knowledge about what impacts emotion dysregulation is limited. Attachment style is related to both emotion regulation and OCD symptoms, but the link between them has not been thoroughly studied. Examining emotion dysregulation within the context of OCD through an attachment theory framework may lead to a better understanding of the aetiology and maintenance of OCD.
View Article and Find Full Text PDFEEG microstate analysis and machine learning classification in patients with obsessive-compulsive disorder.
J Psychiatr Res
January 2025
Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China. Electronic address:
Background: Microstate characterization of electroencephalogram (EEG) is a data-driven approach to explore the functional changes and interrelationships of multiple brain networks on a millisecond scale. This study aimed to explore the pathological changes of whole-brain functional networks in patients with obsessive-compulsive disorders (OCD) through microstate analysis and further to explore its potential value as an auxiliary diagnostic index.
Methods: Forty-eight OCD patients (33 with more than moderate anxiety symptoms, 15 with mild anxiety symptoms) and 52 healthy controls (HCs) were recruited.
Demographics, psychiatric comorbidities, and hospital outcomes across eating disorder types in adolescents and youth: insights from US hospitals data.
Front Child Adolesc Psychiatry
May 2024
Department of Psychiatry & Behavioral Sciences, School of Medicine, Duke University, Durham, NC, United States.
Objective: The aim of our study was to delineate the differences in demographics, comorbidities, and hospital outcomes by eating disorder types in adolescents and transitional-age youth (15-26 years), and measure the association with psychiatric comorbidities.
Methods: We conducted a cross-sectional study using the nationwide inpatient sample (2018-2019) and included 7,435 inpatients (age 12-24 years) with a primary diagnosis of eating disorders: anorexia nervosa (AN, 71.7%), bulimia nervosa (BN, 4.
According to the metacognitive theory, maladaptive metacognition is associated with the development and maintenance of emotional disorders. This study is the first to explore maladaptive metacognition in a sample of children and adolescents (7-17 years) with obsessive-compulsive disorder (OCD) in the context of cognitive behavioral therapy (CBT). A total of 114 children and adolescents were included in the study.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!