AI Article Synopsis
- BH3-only proteins regulate Bcl-2 family members to trigger apoptosis.
- The lack of these proteins in Drosophila has made studying cell death mechanisms in this organism challenging.
- Recent research has discovered a BH3-only protein in flies, which may enhance our understanding of the Bcl-2 pathway across different species.
Article Abstract
BH3-only proteins are key regulators of Bcl-2 family members to activate apoptosis. The absence of a BH3-only protein in Drosophila has complicated the understanding of how Bcl-2 family members contribute to cell death in this model organism. Recent work published in The EMBO Journal reports on the identification of a BH3-only protein in flies. The reported findings may help to clarify the functional role and molecular mechanisms of the highly conserved Bcl-2 pathway in divergent organisms.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106981 | PMC |
| http://dx.doi.org/10.15252/embj.2023113980 | DOI Listing |
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