AI Article Synopsis

  • - The study analyzes the rising rates of bloodstream infections (BSI) in Queensland, Australia, from 2000 to 2019, discovering that the standard incidence rate nearly doubled during this period, reaching 65.9 cases per 100,000 residents.
  • - Key factors contributing to higher BSI rates include older age (65+ years), existing health conditions, and infections originating from the community, with an overall annual increase in BSI incidence rate estimated at 4%.
  • - Notably, there has been a significant rise in extended-spectrum beta-lactamase (ESBL-Ec) producing isolates, particularly after 2010, which poses a growing concern for public health due to its implications within the community

Article Abstract

Background: There is increasing morbidity and mortality attributed to escalating incidence of bloodstream infection (BSI). The epidemiology of BSI is dynamic and differs across populations. This study aimed to describe this epidemiology in Queensland, Australia.

Methods: Incident BSIs (new or recurring ≥30 days from previous BSI) in adult (≥15 years) Queenslanders were identified from 2000 to 2019 using Queensland Health databases. Incidence rates, crude and standardized by age and gender, were calculated. Negative binomial regressions were performed to determine predictors of BSI incidence.

Results: From 2000 to 2019, 30 350 BSIs in 27 793 patients were detected; the standardized incidence rate almost doubled from 34.1 to 65.9 cases per 100 000 residents. Predictors of higher incidence rate were older age (≥65 years), comorbidity, and community-onset infection. Despite holding these factors constant, the incidence rate was estimated to increase 4% (adjusted incidence rate ratio [IRR], 1.04; 95% CI, 1.03-1.04) annually over the study period. Approximately 4.2% of isolates produced extended-spectrum beta-lactamase (ESBL-Ec), with most (95%) detected after 2010. The incidence rate of ESBL-Ec increased 25% (IRR, 1.25%; 95% CI, 1.2-1.3) annually, significantly faster than that of non-producers. Amikacin and carbapenems remain effective in vitro against ESBL-Ec BSI in Queensland.

Conclusions: The rise in BSIs is driven both by a higher infection rate and shifting epidemiology toward community-onset infections. These are likely attributed to an aging Australian population with increasing chronic comorbidity. The rapid expansion of ESBL-Ec in recent years is concerning and should be acknowledged for its implication in the community.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034595PMC
http://dx.doi.org/10.1093/ofid/ofad071DOI Listing

Publication Analysis

Top Keywords

incidence rate
20
2000 2019
12
bloodstream infection
8
incidence
7
rate
6
bsi
5
population-based incidence
4
incidence characteristics
4
characteristics adult
4
adult bloodstream
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!