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| http://dx.doi.org/10.1002/ped4.12362 | DOI Listing |
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Inflammatory Bowel Diseases and Nephropathies: Exploring the Gut-Kidney Axis.
Life (Basel)
November 2024
IBD Unit, Department of Clinical Medicine and Surgery, University Federico II, 80126 Naples, Italy.
Inflammatory bowel disease (IBD) can extend beyond the gastrointestinal tract, affecting extraintestinal organs and significantly increasing morbidity and mortality. Despite early studies revealing kidney involvement in nearly a quarter of patients with IBD, renal manifestations have been notably overlooked. Among these manifestations, nephrolithiasis, obstructive uropathy, and fistula formation between the bowel and urinary tract are the most reported occurrences.
View Article and Find Full Text PDFDeep learning-based histopathological assessment of tubulo-interstitial injury in chronic kidney diseases.
Commun Med (Lond)
January 2025
Department of Dermatology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Background: Chronic kidney disease (CKD) causes progressive and irreversible damage to the kidneys. Renal biopsies are essential for diagnosing the etiology and prognosis of CKD, while accurate quantification of tubulo-interstitial injuries from whole slide images (WSIs) of renal biopsy specimens is challenging with visual inspection alone.
Methods: We develop a deep learning-based method named DLRS to quantify interstitial fibrosis and inflammatory cell infiltration as tubulo-interstitial injury scores, from WSIs of renal biopsy specimens.
A preclinical study on effect of betanin on sodium fluoride induced hepatorenal toxicity in wistar rats.
J Complement Integr Med
January 2025
Department of Basic Medical Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Article Synopsis
- Excessive fluoride exposure can cause oxidative stress and damage metabolic organs, leading to toxicity in the liver and kidneys.
- A study was conducted on Wistar rats divided into four groups, with some receiving sodium fluoride alone and others receiving fluoride with different doses of betanin from beetroot for 90 days.
- Results showed that betanin treatment reduced markers of liver and kidney damage and improved oxidative stress indicators, suggesting it could potentially protect against fluoride-induced organ toxicity.
Snakebite envenomation-associated acute kidney injury: a South-Asian perspective.
Trans R Soc Trop Med Hyg
January 2025
Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India.
Snakebite is a neglected public health problem in tropical countries. Snakebite envenomation-associated acute kidney injury (SBE-AKI) is a major complication accounting for significant morbidity and mortality. The pathogenesis of SBE-AKI may be multifactorial, including prerenal AKI secondary to hemodynamic alterations, intrinsic renal injury, immune-related mechanisms, venom-induced consumptive coagulopathy and capillary leak syndrome.
View Article and Find Full Text PDFRate and yield of imaging for acute pyelonephritis in the emergency department: A retrospective cohort study.
Emerg Med Australas
February 2025
Emergency Service, Alfred Health, Melbourne, Victoria, Australia.
Objectives: The role of imaging in acute pyelonephritis (APN) in the ED is poorly understood, with variability among clinical guidelines for when patients should be imaged, and the modality of imaging. The objective of this study was to identify the proportion of patients with APN being imaged, the proportion abnormal findings, and the association between abnormal imaging and discharge disposition.
Methods: A single-centre retrospective review of patients with a discharge diagnosis of APN at an adult tertiary referral hospital over a 5-year period (2018-2022) was conducted.
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