AI Article Synopsis
- The study aimed to find the effective doses of rocuronium that would depress muscle twitch response in dogs under alfaxalone anesthesia.
- It included eight Beagle dogs, monitored through neuromuscular function to measure the effect of different doses of rocuronium (100, 175, and 250 μg/kg).
- Results showed that the effective doses were 175 μg/kg for ED and 232 μg/kg for ED, with longer recovery times corresponding to higher doses of rocuronium.
Article Abstract
Objective: To determine the median effective dose (ED) and effective dose required to depress the twitch value by 95% (ED) of rocuronium during alfaxalone anesthesia in dogs.
Study Design: A randomized, prospective, crossover experimental study.
Animals: A total of eight adult Beagle dogs (four female, four male), weighing 10.3-14.6 kg and aged 6-8 years.
Methods: The dogs were anesthetized three times with 1.25-fold the individual minimum infusion rate of alfaxalone at intervals of ≥ 14 days. Neuromuscular function was monitored with train-of-four (TOF) stimulation of the peroneal nerve by acceleromyography. After recording the control TOF ratio (TOFRC) and first twitch of TOF (T1C), a single bolus dose of rocuronium 100, 175 or 250 μg kg (treatments R100, R175 or R250) was administered intravenously. The maximum suppression of the first twitch of TOF (T1) was recorded and calibrated with T1C to construct the dose-response curve, from which ED and ED were calculated. Time from rocuronium administration to TOF ratio/TOFRC > 0.9 (duration TOFR0.9) was recorded.
Results: ED and ED of rocuronium during alfaxalone anesthesia were 175 and 232 μg kg, respectively. The median (range) duration TOFR0.9 was longer in treatment R250 [10.1 (9.2-10.9) minutes] than in treatments R100 [3.1 (2.9-4.4) minutes; p < 0.0001] and R175 [7.7 (6.9-8.1) minutes; p < 0.0001]; and longer in treatment R175 than in treatment R100 (p < 0.0001).
Conclusions And Clinical Relevance: The duration of TOFR0.9 correlated positively with the dosage of rocuronium, indicating that recovery time of rocuronium was also dose-dependent in dogs anesthetized with alfaxalone. The duration TOFR0.9 of rocuronium 250 μg kg was 10 minutes during alfaxalone anesthesia in dogs.
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| http://dx.doi.org/10.1016/j.vaa.2023.02.008 | DOI Listing |
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