AI Article Synopsis
- Periodontal disease is a prevalent inflammatory disorder in humans, with gingivitis being the mildest form that can progress to more severe periodontitis, affecting both soft tissues and bone.
- Myeloid-derived suppressor cells (MDSCs) play a key role in this disease, as they are immature immune cells that can suppress T cell activity and are involved in the inflammatory response associated with periodontal disease.
- The review highlights recent progress in understanding the biology of MDSCs, including their subtypes, movement within the body, and their roles in immune suppression and bone loss in the context of periodontal infections.
Article Abstract
Periodontal disease is one of the most common inflammatory disorders in humans. Gingivitis is the mildest form of periodontal disease and its progression can lead to periodontitis, an inflammatory disease characterized by soft tissue damage that can lead to progressive destruction of the periodontal ligament and alveolar bone. Diverse populations of immune cells are involved in periodontal disease. Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous group of immature myeloid cells derived from hematopoietic precursor cells and exhibit T cell immunosuppressive functions that are thought to be involved in periodontal disease. Therefore, MDSCs have been recently analyzed in the context of this disease. In this review, we discuss the most recent advances in the characterization of the biological aspects, subpopulations, and traffic of MDSCs, as well as their immunosuppressive and osteoclastogenic activity in the context of periodontal disease and in the presence of key periodontal pathogens.
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| http://dx.doi.org/10.1016/bs.ircmb.2022.12.001 | DOI Listing |
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