AI Article Synopsis
- Cutaneous leishmaniasis (CL) is a neglected tropical disease with limited treatment options, prompting the exploration of antimicrobial photodynamic therapy (APDT) using natural compounds as potential photosensitizers.
- This study tested three natural anthraquinones (AQs) on CL in infected mice, assessing treatment effects with different light wavelengths and compounds.
- Results showed that one treatment effectively maintained low parasite levels and reduced lesion size, indicating that these natural AQs could be a viable solution for CL, warranting further investigation into their immune responses.
Article Abstract
Background: Cutaneous leishmaniasis (CL) is an important tropical neglected disease with broad geographical dispersion. The lack of effective drugs has raised an urgent need to improve CL treatment, and antimicrobial photodynamic therapy (APDT) has been investigated as a new strategy to face it with positive outcomes. Natural compounds have emerged as promising photosensitizers (PSs), but their use in vivo remains unexplored.
Purpose: In this work, we investigated the potential of three natural anthraquinones (AQs) on CL induced by Leishmania amazonensis in BALB/c mice.
Study Design/methods: ANIMALS WERE INFECTED AND RANDOMLY DIVIDED INTO FOUR GROUPS: CG (control, non-treated group), G5ClSor-gL (treated with 5-chlorosoranjidiol and green LED, 520±10 nm), GSor-bL and GBisor-bL (treated with soranjidiol and bisoranjidiol, respectively, exposed to violet-blue LED, 410±10 nm). All AQs were assayed at 10 μM and LEDs delivered a radiant exposure of 45 J/cm with an irradiance of 50 mW/cm. We assessed the parasite burden in real time for three consecutive days. Lesion evolution and pain score were assessed over 3 weeks after a single APDT session.
Results: G5ClSor-gL was able to sustain low levels of parasite burden over time. Besides, GSor-bL showed a smaller lesion area than the control group, inhibiting the disease progression.
Conclusion: Taken together, our data demonstrate that monoAQs are promising compounds for pursuing the best protocol for treating CL and helping to face this serious health problem. Studies involving host-pathogen interaction as well as monoAQ-mediated PDT immune response are also encouraged.
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| http://dx.doi.org/10.1016/j.pdpdt.2023.103525 | DOI Listing |
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