AI Article Synopsis
- Halo nevus, also known as Sutton's nevus, is characterized by nevus cells surrounded by vitiligo, and its immune response remains unclear despite treatment often failing to improve vitiligo.
- A study involving 54 halo nevus patients analyzed clinical outcomes and the immune environment, finding that only the presence of vitiligo vulgaris influenced surrounding vitiligo improvement post-excision.
- The research indicated that non-improved cases had a higher expression of programmed death-ligand 1 and a dense infiltration of certain immune cells, while improved cases showed more active cell interactions and specific immune cell types.
Article Abstract
Background: Halo nevus, also called Sutton's nevus, is a nevus cell nevus surrounded by vitiligo thought to be caused by a T-cell mediated immune response to the nevus antigen. The immune microenvironment is mysterious, however, as vitiligo often does not improve even when the nevus cells are removed.
Objectives: To analyze the clinical course and immune microenvironment of patients with halo nevus who had undergone nevus excision.
Methods: We collected 54 halo nevus patients and performed multivariate analysis and immunohistochemical analysis, including multiplexed immune cell phenotyping and spatial single-cell analyses using the PhenoCycler® assay.
Results: Multivariate analysis revealed that only the presence or absence of vitiligo vulgaris at the time of consultation was associated with improvement in the surrounding vitiligo following excision. Expression of programmed death-ligand 1 in nevus cells was significantly higher in non-improved cases compared with improved cases. The PhenoCycler® assay revealed that CD107a-positive and CD21-positive cells were more prevalent in improved cases than in non-improved cases. In the improved cases, active cell-cell interactions, centered on CD21-positive cells, were observed, whereas in the non-improved cases, cell-cell interactions were sparse. Instead, a dense infiltration of CD8-positive cells and CD3 and CD4-positive cells was observed in non-improved cases.
Conclusion: Elucidation of the immune microenvironment of halo nevus is also relevant to melanoma-associated vitiligo and will contribute to our understanding of tumor immunity.
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| http://dx.doi.org/10.1016/j.jdermsci.2023.03.004 | DOI Listing |
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