Abnormal viscosity and excessive superoxide anion (O) levels in living cells often cause a series of biological dysfunction and oxidative damage. However, a great challenge remains in quickly and conveniently detecting the viscosity and O levels in living cells. Herein, we fabricated a versatile aggregation-induced emission (AIE) probe with mitochondria targeting, DTPB, for dual-imaging of viscosity and O level in living cells with two different channels. The obtained DTPB contained a diphenyl phosphinic acid unit responsive to O, a unit with twisted intramolecular charge trans (TICT) function responsive to viscosity, and a pyridine cation unit with mitochondria targeting. The results showed that DTPB exhibited a remarkable response to viscosity with a near-infrared emission peak at 671 nm and was highly sensitive to O levels with an emission peak at 587 nm. The dual-channel probe has great application prospects in the visual diagnosis of cancer and related diseases.
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| http://dx.doi.org/10.1016/j.aca.2023.341099 | DOI Listing |
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