AI Article Synopsis
- Takayasu arteritis (TAK) is an autoimmune disease that affects major blood vessels, potentially leading to serious complications like aortic aneurysms and blockages, and this study explores the link between gut bacteria and these complications in TAK patients.* -
- Researchers analyzed the gut microbiomes of 76 TAK patients and 56 healthy controls, finding that TAK patients had higher levels of oral bacteria, especially Campylobacter, which were related to the need for surgical interventions for aortic issues.* -
- The study suggests that the presence of specific gut bacteria, such as Campylobacter gracilis, could be an important indicator for predicting worsening aortic conditions in patients with TAK.*
Article Abstract
Background: Takayasu arteritis (TAK) is an autoimmune large vessel vasculitis that affects the aorta and its major branches, eventually leading to the development of aortic aneurysm and vascular stenosis or occlusion. This retrospective and prospective study aimed to investigate whether the gut dysbiosis exists in patients with TAK and to identify specific gut microorganisms related to aortic aneurysm formation/progression in TAK.
Methods: We analysed the faecal microbiome of 76 patients with TAK and 56 healthy controls (HCs) using 16S ribosomal RNA sequencing. We examined the relationship between the composition of the gut microbiota and clinical parameters.
Results: The patients with TAK showed an altered gut microbiota with a higher abundance of oral-derived bacteria, such as Streptococcus and Campylobacter, regardless of the disease activity, than HCs. This increase was significantly associated with the administration of a proton pump inhibitor used for preventing gastric ulcers in patients treated with aspirin and glucocorticoids. Among patients taking a proton pump inhibitor, Campylobacter was more frequently detected in those who underwent vascular surgeries and endovascular therapy for aortic dilatation than in those who did not. Among the genus of Campylobacter, Campylobacter gracilis in the gut microbiome was significantly associated with clinical events related to aortic aneurysm formation/worsening in patients with TAK. In a prospective analysis, patients with a gut microbiome positive for Campylobacter were significantly more likely to require interventions for aortic dilatation than those who were negative for Campylobacter. Furthermore, patients with TAK who were positive for C. gracilis by polymerase chain reaction showed a tendency to have severe aortic aneurysms.
Conclusions: A specific increase in oral-derived Campylobacter in the gut may be a novel predictor of aortic aneurysm formation/progression in patients with TAK.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037851 | PMC |
| http://dx.doi.org/10.1186/s13075-023-03031-9 | DOI Listing |
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