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Ascorbic acid assisted photodegradation of methylcobalamin using corrective irrelevant absorption spectrophotometric assay: A kinetic study.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Super Highway, Gadap Road, Karachi, Pakistan.
Article Synopsis
- Photodegradation of drug substances can produce both known and unknown products that interfere with analytical results due to absorption at certain wavelengths.
- The study focuses on improving the accuracy of measurements for methylcobalamin (MC) and hydroxocobalamin by applying linear and non-linear methods to correct for irrelevant absorbances during photolytic degradation involving ascorbic acid (AH).
- Methylcobalamin shows first-order degradation kinetics, with the degradation rate being pH-dependent; it peaks at pH 5.0 when in the presence of ascorbic acid, whereas degradation slows down in more alkaline conditions.
Hydroxocobalamin is not associated with methemoglobinemia in patients with inhalation injury and suspected cyanide toxicity and a proposed algorithm for hydroxocobalamin administration.
Burns
September 2024
Department of Plastic and Reconstructive Surgery, University of Southern California, Los Angeles, CA, USA; Department of Surgery, Los Angeles General Medical Center, Los Angeles, CA, USA. Electronic address:
Background: Cyanide poisoning poses a significant threat to burn patients exposed to smoke in residential or workplace fires, leading to central nervous system dysfunction, hemodynamic instability, cardiovascular collapse, and death. Prompt administration of an effective antidote is critical. Hydroxocobalamin, a form of vitamin B12, is the gold standard treatment for cyanide toxicity, by binding to cyanide molecules and converting them into non-toxic cyanocobalamin that is eliminated by the kidneys.
View Article and Find Full Text PDFElevated methemoglobin levels in patients treated with high-dose hydroxocobalamin.
Lab Med
January 2024
Memorial Cardiac & Vascular Institute, Memorial Healthcare System, Hollywood, FL, US.
Objective: The aim of this study was to assess the impact of hydroxocobalamin (OHCbl) infusion on arterial blood gas and oximetry values in patients with vasoplegic syndrome.
Methods: Blood samples collected from 95 patients receiving OHCbl infusion were assayed using the ABL90 FLEX Plus blood gas analyzer for the concentration of methemoglobin (MetHb), total hemoglobin (tHb), carboxyhemoglobin (COHb), arterial oxygen saturation (SaO2), arterial oxygen partial pressure (PaO2), and arterial carbon dioxide partial pressure (PaCO2). Interference of OHCbl on these variables was evaluated using the measured difference between the preinfusion and postinfusion samples.
Seeing Red: Hydroxocobalamin and Result Interference.
J Cardiothorac Vasc Anesth
August 2023
Department of Anesthesia, Critical Care and Pain Medicine, Veterans Affairs Boston Healthcare System, Tufts University School of Medicine, Boston, MA. Electronic address:
Hydroxocobalamin Interference With Chromogenic Anti-Xa Assay in a Patient on Mechanical Circulatory Support.
J Cardiothorac Vasc Anesth
July 2023
Department of Pharmacy, Rhode Island Hospital, Providence, RI. Electronic address:
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