The roll out of COVID-19 vaccines has again revealed the gap between high income countries and developing nations in terms of access to healthcare commodities and services. With the slow vaccination roll out in many low income countries and the emergence of more contagious variants of COVID-19, many persons are at risk of contracting the disease in settings with low immunisation coverage. This study aimed at exploring the views of healthcare practitioners on the role of patent waivers and compulsory licensing in facilitating access to vaccines. A cross-sectional study was undertaken among practitioners in the health sector, which comprised private, public, and development agencies. A well structured and validated questionnaire was administered to the study participants using both physical and online methods of administration in Nigerian setting. A total of 526 respondents participated in the study, majority of them were males (54.4%). A third of the study participants (31.1%) had postgraduate degrees. A strong majority of the respondents (81.2%) agreed that the role of patent is to promote innovation, whilst 70.6% of them indicated that intellectual property waivers can improve access to COVID-19 vaccines. Slightly above half of the respondents (56.0%) indicated that patent waivers can reduce innovation in the pharmaceutical sector, they however indicated that such challenge can be mitigated by granting incentives to innovators whose intellectual property rights had been waived. This study has revealed that there is a need for intellectual property rights waiver and compulsory licensing of all novel COVID-19 commodities including vaccines, as this is an important strategy that can improve access to relevant products in developing countries.
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http://dx.doi.org/10.1371/journal.pgph.0000683 | DOI Listing |
Ann Thorac Surg Short Rep
September 2023
Department of Cardiovascular Surgery, Iwate Prefectural Central Hospital, Morioka, Iwate, Japan.
Background: A strategy combining tear-oriented initial surgical procedure and subsequent thoracic endovascular aortic repair (TEVAR) can be adopted for acute type A aortic dissection (ATAAD). This study investigated this strategy's outcomes and the role of the aortic hiatus (AH).
Methods: Overall, 192 consecutive patients with ATAAD who underwent initial surgery between 2012 and 2021 were assessed in this observational retrospective study.
Combined immune checkpoint blockade (ICB) and chemoradiation (CRT) is approved in patients with locally advanced cervical cancer (LACC) but optimal sequencing of CRT and ICB is unknown. NRG-GY017 (NCT03738228) was a randomized phase I trial of atezolizumab (anti-PD-L1) neoadjuvant and concurrent with CRT (Arm A) vs. concurrent with CRT (Arm B) in patients with high-risk node-positive LACC.
View Article and Find Full Text PDFJ Pain Symptom Manage
January 2025
Department of Medicine, NYU Grossman School of Medicine; HIGN, NYU Rory Meyers College of Nursing.
Context: Chronic kidney disease (CKD) disproportionately impacts lower socioeconomic groups and is associated with many symptoms and complex decisions. Integration of Kidney Supportive Care (KSC) with CKD care can address these needs. To our knowledge, this approach has not been described in an underserved population.
View Article and Find Full Text PDFJ Psychosom Res
January 2025
Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:
Objective: Our aim was to explore the joint impacts of depressive symptoms along with triglyceride-glucose index (TyGi) on major adverse cardiovascular events (MACE) in patients who have acute coronary syndrome (ACS) and investigate whether the impact of depressive symptoms on MACE is mediated through the TyGi.
Methods: This extensive cohort study included 3681 ACS patients. Depressive symptoms and TyGi were assessed at baseline, and the patients were subsequently followed for two years to monitor the occurrence of MACE.
PLoS One
January 2025
Maple Health Group, LLC, New York, United States of America.
The US faces substantial demographic and geographic disparities in both HIV burden and access to pre-exposure prophylaxis (PrEP), an effective strategy to prevent HIV acquisition. Long-acting cabotegravir (CAB) is a novel, injectable PrEP option which demonstrated superior reduction in risk of HIV acquisition compared to daily-oral PrEP in the HPTN083 trial. We modelled the impact of increased PrEP initiations and the introduction of long-acting CAB on HIV incidence among men who have sex with men (MSM) in Atlanta, Georgia, a population with a high burden of HIV.
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