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| http://dx.doi.org/10.4274/balkanmedj.galenos.2023.2023-3-15 | DOI Listing |
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Structural and functional connectomics of the olfactory system in Parkinson's disease: a systematic review.
Parkinsonism Relat Disord
December 2024
Brain Mapping Lab, Department of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy. Electronic address:
Olfactory dysfunction, affecting 75-90 % of Parkinson's disease (PD) patients, holds significant predictive value for PD development. Advanced imaging techniques, such as diffusion MRI (dMRI) and functional MRI (fMRI), offer insights into structural and functional changes within olfactory pathways. This review summarizes a decade of research on MRI-based connectivity of the olfactory system in PD, focusing on structural and functional alterations in olfactory brain areas and their links to early olfactory processing changes.
View Article and Find Full Text PDFEnhancing colonic health with encapsulated grape seed anthocyanins: Oral capsule for Colon-targeted delivery.
Food Chem
December 2024
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China; School of Food Science and Technology, Jiangnan University, Wuxi, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, China. Electronic address:
Grape seed anthocyanins (GSA) offer health benefits and protect against diseases, including colitis. Its unpleasant smell and instability prevent widespread application. Antisolvent pretreatment GSA was encapsulated in chitosan-phytic acid 3D gel network.
View Article and Find Full Text PDFOlfactory cleft brushing: A minimally invasive tool for biomarker analysis in rhinology.
Am J Otolaryngol
December 2024
Department of Otorhinolaryngology, University of Rome Tor Vergata, Rome 00133, Italy.
Introduction: Olfactory dysfunction is a prevalent condition associated with post-viral syndromes, chronic rhinosinusitis, and neurodegenerative diseases. While olfactory cleft sampling has been investigated in neurology, its potential for assessing localized biomarkers in rhinological conditions remains underexplored. This study presents a minimally invasive nasal brushing technique specifically targeting the olfactory cleft, enabling simultaneous biomarker quantification and cytological analysis.
View Article and Find Full Text PDFMultidimensional Effects of Stress on Neuronal Exosome Levels and Simultaneous Transcriptomic Profiles.
Biol Psychiatry Glob Open Sci
January 2025
Department of Psychiatry, New York University Grossman School of Medicine, New York, New York.
Background: An excess of exosomes, nanovesicles released from all cells and key regulators of brain plasticity, is an emerging therapeutic target for stress-related mental illnesses. The effects of chronic stress on exosome levels are unknown; even less is known about molecular drivers of exosome levels in the stress response.
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A rapid approach based on empirical formulas and graph traversal algorithms to automatic generation of fragrance formulas.
Heliyon
December 2024
Technology Center of China Tobacco Hunan Industrial Co., Ltd., Changsha, 410007, China.
This article proposes a novel approach for improving the efficiency of fragrance designing and the accuracy of automatic fragrance formula creation based on empirical fragrance formulas and graph traversal algorithms. By effectively extracting the composition information and further analyzing the combination of fragrance materials in 210 fragrance formulas, a relational network model was constructed in the form of a graph to illustrate the relationship between the ingredients used in the formulas. Additionally, a fragrance ingredients information database of 344 common ingredients was constructed and used as a reference for perfumers when setting algorithmic constraints based on their experience.
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