Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0076-6879(87)49060-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Application of Strontium Chloride Hexahydrate to Synthesize Strontium-Substituted Carbonate Apatite as a pH-Sensitive, Biologically Safe, and Highly Efficient siRNA Nanocarrier.
ACS Appl Bio Mater
December 2024
Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia.
Naked siRNAs are sensitive to enzymatic degradation, phagocytic entrapment, quick renal excretion, membrane impermeability, endosomal escape, and off-target effects. Designing a safe and efficient nanocarrier for siRNA delivery to the target site without toxicity remains a significant hurdle in gene therapy. CA is a unique derivative of hydroxyapatite and a highly pH-sensitive nanocarrier with strong particle aggregation and a high polydispersity index.
View Article and Find Full Text PDFEngineered cell membrane-cloaked metal-organic framework nanocrystals for intracellular cargo delivery.
J Colloid Interface Sci
March 2025
Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Física de Partículas, Universidade de Santiago de Compostela, 15705 Santiago de Compostela, Spain. Electronic address:
This investigation demonstrates the development and functionality of cell membrane-cloaked UiO-67 nanosized metal-organic frameworks (NMOFs), which are engineered for precise intracellular delivery of encapsulated cargoes. Utilizing the robust and porous nature of UiO-67, we enveloped these NMOFs with fusogenic cell membrane-derived nanovesicles (FCSMs) sourced from adenocarcinomic human alveolar basal epithelial (A549) cells. This biomimetic coating enhances biocompatibility and leverages the homotypic targeting capabilities of the cell-derived coatings, facilitating direct cytoplasmic delivery and avoiding endolysosomal entrapment.
View Article and Find Full Text PDFFacile pyrolysis synthesis of abundant FeCo dual-single atoms anchored on N-doped carbon nanocages for synergistically boosting oxygen reduction reaction.
J Colloid Interface Sci
October 2023
College of Chemistry and Materials Science, College of Geography and Environmental Sciences, Key laboratory of the Ministry of Education for Advanced Catalysis Materials, Zhejiang Normal University, Jinhua, 321004, PR China. Electronic address:
Single-atom transition metal-based nitrogen-doped carbon (M-N-C) is regarded as high-efficiency and cost-effectiveness alternatives to replace noble metal catalysts for oxygen reduction reaction (ORR) in renewable energy storage and conversion devices. In this work, rich FeCo dual-single atoms were efficiently entrapped into N-doped carbon nanocages (FeCo DSAs-NCCs) by simple pyrolysis of the bimetallic precursors doped zeolitic imidazolate framework-8 (ZIF-8), as affirmed by a series of characterizations. The graphitization degree of the N-doping carbon substrate was regulated by modulating the pyrolysis temperature and the types of the metal salts.
View Article and Find Full Text PDFA small-molecule carrier for the intracellular delivery of a membrane-impermeable protein with retained bioactivity.
Proc Natl Acad Sci U S A
October 2024
College of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China.
Article Synopsis
- Intracellular protein delivery has significant potential in cell biology and medicine, aiding in areas like bioimaging, disease treatment, and genome editing.* -
- Researchers successfully delivered the functional protein cytochrome c (CYC) into lipid vesicles and live cells using a boron cluster anion carrier, achieving a cellular uptake rate of nearly 90%.* -
- The method allowed CYC to enter the cytoplasm directly while maintaining its biological activity, showing a 25% increase in cell apoptosis at a low dose, highlighting the efficiency of inorganic cluster ions as protein delivery tools for future applications.*
Sodium-Ion Traps in a Two-Dimensional Confined Channel for Effective Water and Ion Selective Transport.
Nano Lett
October 2024
Research Center for Membrane and Film Technology, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan.
Article Synopsis
- * This study introduces sodium-ion traps (SITs) in graphene oxide channels by adding NPCE, which helps control the ion-diffusion energy barriers for enhanced ion transport.
- * The optimized membrane showed high efficiency in rejecting specific ions like NaSO and NaCl while maintaining stable performance over 1500 hours, offering new strategies for manipulating ion transport in 2D materials.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!