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A Novel Tumor Hypoxia Imaging Agent: [Tc]Tc(CO)-CPA-2-NIM. | LitMetric

A Novel Tumor Hypoxia Imaging Agent: [Tc]Tc(CO)-CPA-2-NIM.

Curr Radiopharm

Department of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266000, China.

Published: September 2023

Introduction: Hypoxia imaging agents can selectively remain in hypoxic tissue, which can directly reflect the location and degree of hypoxia.

Methods: Synthesized a novel tumor hypoxia imaging probe [Tc]Tc(CO)-CPA-2-NIM and evaluated its biological behavior with the purpose to assess its possibility of becoming a qualified tumor hypoxia imaging agent.

Results: Radiochemcial purity of [Tc]Tc(CO)-CPA-2-NIM was greater than 95% after HPLC purification. Lipophilicity coefficient of this complex was -1.74 ± 0.10 (n = 5, number of experiments), indicating it was a hydrophilic complex. cell experiments demonstrated that this complex has selectivity for hypoxia at oxygen concentrations < 10 ppm (parts per million). Biodistribution experiment in S180 tumor bearing mice showed that tumor uptake reached its highest at 2 h post-injection with mice tumor-to-muscle ratio.

Conclusions: Complex [Tc]Tc(CO)-CPA-2-NIM has the possibility of becoming a tumor hypoxia imaging agent.

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Source
http://dx.doi.org/10.2174/1874471016666230320144641DOI Listing

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