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Recruiting African American Prostate Cancer Survivors for a Population-based Biobank Study. | LitMetric

AI Article Synopsis

  • Prostate cancer notably affects African American men more than other racial/ethnic groups, prompting a study to create a biobank of survivors in Florida to explore biological reasons for this disparity.* -
  • The study identified 5,960 eligible individuals, reaching out to them led to 578 consenting participants, resulting in a consent rate of only 10%, despite some demographic differences noted between those who consented and those who did not.* -
  • The findings highlight the feasibility of recruiting African American prostate cancer survivors for research but emphasize the need for improved strategies to enhance participation and address consent challenges in cancer studies.*

Article Abstract

Background: Prostate cancer affects African American men disproportionately compared with men of other racial/ethnic groups. To identify biological bases for this health disparity, we sought to create a state-wide biobank of African American prostate cancer survivors in Florida.

Methods: African American men diagnosed with prostate cancer between 2013 and 2017 and living in Florida at diagnosis were identified through the State of Florida's cancer registry. Individuals were approached via mail and telephone, assessed for eligibility, and asked for informed consent. χ2 and t tests were conducted to identify differences between eligible and reachable individuals (i.e., had valid contact information) versus consented participants.

Results: Of the 5,960 eligible and reachable individuals, 3,904 were eligible and contacted at least once, and 578 consented [overall consent rate = 10% (578/5,960); adjusted consent rate = 15% (578/3,904)]. Statistically significant (Ps < 0.05) but small differences in demographic and clinical variables were observed. Consented participants were less likely to be older than 64 (35% vs. 41%) and less likely to have received radiotherapy (36% vs. 41%) and hormone therapy (16% vs. 21%), but more likely to have regional prostate cancer (13% vs. 11%) and have undergone surgery (44% vs. 39%). Consented participants did not differ from reachable individuals on other demographic and clinical factors (Ps > 0.05).

Conclusions: Recruiting African American prostate cancer survivors to biobanking research through a cancer registry is feasible. However, the consent rate was low, and existing challenges limit consent and participation.

Impact: Strategies for overcoming barriers to informed consent and increasing participation in biospecimen research are needed to address cancer disparities.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308568PMC
http://dx.doi.org/10.1158/1055-9965.EPI-22-1157DOI Listing

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