Non-toxic and biodegradable κ-carrageenan/ZnO hydrogel for adsorptive removal of norfloxacin: Optimization using response surface methodology.

Antibiotic resistance is increasing globally due to increased prescription and easy dispensing of antibiotic drugs universally. Hence, to mitigate this effect, efficient, biodegradable, and non-toxic adsorbents are required to be developed. Carrageenan (CG), a natural polymer, having multiple functional groups, provides a backbone for crosslinking with borax and incorporation of ZnO nanoparticles that formed borax-cross-linked κ-carrageenan (CG/Bx/ZnO) hydrogel which is used for efficient adsorption of norfloxacin from water. Surface morphology of as-synthesized hydrogel revealed the rough surface, which was determined by FESEM. Surface area of CG/Bx/ZnO hydrogel was found to be 22.90 m/g with 3.41 nm pore radius. Systematic batch adsorption studies revealed that 99.4 % removal efficiency could be achieved at a dosage level of 20 mg/L of norfloxacin with 10 mg of hydrogel at pH of 4 in 8 h at room temperature. Experimentally optimized key parameters affecting the overall efficiency of adsorption matched well with the results assessed from ANOVA using Box-Behnken composite design model. The adsorption process was well fitted with the pseudo-second-order model and Langmuir isotherm with 1282.05 mg/g adsorption capacity. Thermodynamic study results show that adsorption is spontaneous and endothermic. The CG/Bx/ZnO hydrogel demonstrated excellent repeatability with minimal loss in norfloxacin adsorption for seven cycles.