AI Article Synopsis
- The study aimed to find the incidence rate of narcolepsy in South Korea and its connection to other systemic autoimmune diseases.
- Researchers analyzed data from a nationwide health insurance claims database between 2010 and 2019, comparing narcolepsy patients with matched controls.
- They found that narcolepsy has an incidence of 0.05% and is significantly linked to autoimmune diseases like ankylosing spondylitis and rheumatoid arthritis, particularly those associated with HLA genes.*
Article Abstract
Study Objectives: To determine the incidence rate of narcolepsy in South Korea and closely examine the relationship between narcolepsy, which is believed to be an autoimmune response, and other systemic autoimmune diseases.
Methods: We examined data from the South Korean nationwide health insurance claims database from 2010 to 2019. Our study included patients with narcolepsy as well as age- and sex-matched controls without narcolepsy. We estimated the incidence of narcolepsy and the odds ratio of narcolepsy and associated autoimmune comorbidities in South Korea.
Results: We identified 8710 patients with narcolepsy (59.8% men and 40.2% women). The incidence of narcolepsy was 0.05%. Patients with narcolepsy were at a significantly high risk of ankylosing spondylitis, rheumatoid arthritis, and Sjögren's syndrome, which diseases are known to be related to human leukocyte antigen (HLA) genes.
Conclusions: Narcolepsy is closely related to systemic autoimmune diseases, particularly those related to HLA genes.
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| http://dx.doi.org/10.1016/j.sleep.2023.03.006 | DOI Listing |
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Article Synopsis
- Charles Fisher was a groundbreaking researcher in sleep medicine who made significant contributions in various areas of sleep study, particularly concerning REM sleep in narcoleptic patients.
- He was the first to document several key concepts, such as the effects of benzodiazepines on night terrors and the connection between REM sleep and sexual arousal.
- Collaborating with notable figures like William C. Dement, Fisher’s work laid a foundation for understanding sleep disorders, behaviors, and cycles, influencing the field well beyond his era.
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