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Self-Diffusion of Star and Linear Polyelectrolytes in Salt-Free and Salt Solutions.
Macromolecules
January 2025
Department of Materials Science & Engineering, Texas A&M University, College Station, Texas 77840, United States.
This work explored solution properties of linear and star poly(methacrylic acids) with four, six, and eight arms (PMAA, 4PMAA, PMAA, and 8PMAA, respectively) of matched molecular weights in a wide range of pH, salt, and polymer concentrations. Experimental measurements of self-diffusion were performed by fluorescence correlation spectroscopy (FCS), and the results were interpreted using the scaling theory of polyelectrolyte solutions. While all PMAAs were pH sensitive and showed an increase in hydrodynamic radius ( ) with pH in the dilute regime, the of star polymers (measured at basic pH values) was significantly smaller for the star polyacids due to their more compact structure.
View Article and Find Full Text PDFSelf-Directed Violence Among Black Young Adults with Negative Police Experiences.
Community Ment Health J
January 2025
Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, East Baltimore Campus, 615 N Wolfe Street, Baltimore, MD, 21205, USA.
The current study assessed associations between negative experiences with police and self-directed violence (SDV) among a United States (US) sample of Black young adults ages 18-29 reporting lifetime police stops. Data come from the "INtervening on Self-Harm and Policing to Increase Racial Equity" (INSPIRE) survey (N = 672) and were collected between December 2023 and March 2024. This high-risk sample exhibited elevated rates of self-harm ideation or NSSI (27.
View Article and Find Full Text PDFPrimary Antibody Deficiencies: Curation Of Gene-Disease Relationships Using A ClinGen Validation Framework.
J Allergy Clin Immunol
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Nationwide Children's Hospital, Columbus, OH, USA. Electronic address:
Background: The Clinical Genome Resource (ClinGen) is an international collaborative effort between scientists and clinicians, diagnostic and research laboratories as well as the patient community. Using a standardized framework, ClinGen has established guidelines to classify gene-disease relationships as Definitive, Strong, Moderate, and Limited based on available scientific and clinical evidence. When the genetic and functional evidence for a gene-disease relationship has conflicting interpretations or contradictory evidence, they can be Disputed or Refuted.
View Article and Find Full Text PDFLipid Management in US Commercial and Medicare Enrollees with Atherosclerotic Cardiovascular Disease: Treatment Patterns and Low-Density Lipoprotein Cholesterol Control.
Am J Cardiol
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Division of Cardiovascular Medicine and the Cardiovascular Institute, Stanford University School of Medicine, 291 Campus Drive, Stanford, CA, 94305, USA.
Lipid-lowering therapy (LLT) is the cornerstone for secondary prevention of atherosclerotic cardiovascular disease (ASCVD), yet many patients exhibit low adherence to therapy and fail to achieve low-density lipoprotein cholesterol (LDL-C) goals. This retrospective cohort study used 2 nationally representative administrative closed claims databases (PharMetrics® Plus and Medicare Fee-for-Service [FFS] Research Identifiable Files) to identify commercial (C) and Medicare (M) enrollees with ASCVD between 2014-2019. Patients were stratified by exposure to statin therapy, ezetimibe and proprotein convertase subtilisin/kexin type 9 monoclonal antibodies (PCSK9i mAb) regimens.
View Article and Find Full Text PDFPharmacologic Management of Heart Failure with Preserved Ejection Fraction (HFpEF) in Older Adults.
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Program for the Care and Study of the Aging Heart, Department of Medicine, Weill Cornell Medicine, 420 East 70th St, New York, NY, LH-36510063, USA.
There are several pharmacologic agents that have been touted as guideline-directed medical therapy for heart failure with preserved ejection fraction (HFpEF). However, it is important to recognize that older adults with HFpEF also contend with an increased risk for adverse effects from medications due to age-related changes in pharmacokinetics and pharmacodynamics of medications, as well as the concurrence of geriatric conditions such as polypharmacy and frailty. With this review, we discuss the underlying evidence for the benefits of various treatments in HFpEF and incorporate key considerations for older adults, a subpopulation that may be at higher risk for adverse drug events.
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