AI Article Synopsis
- The text describes a new chemical reaction that combines allyl-substituted arenes with electron-deficient alkenes through a process involving cobalt-catalyzed hydrogen atom transfer (HAT).
- This method allows for the efficient formation of complex tetralin products while minimizing issues that usually arise from other reactions like hydrofluorination or radical polymerization.
- The reaction conditions are mild and compatible with various functional groups, making it a versatile tool for creating complex chemical structures that are difficult to achieve with traditional methods like Diels-Alder cycloadditions.
Article Abstract
A radical/polar crossover annulation between allyl-substituted arenes and electron-deficient alkenes is described. Cobalt-catalyzed hydrogen atom transfer (HAT) facilitates tandem radical C-C bond formation that generates functionalized tetralin products in the face of potentially problematic hydrofluorination, hydroalkoxylation, hydrogenation, alkene isomerization, and radical polymerization reactions. The reactions proceed under mild conditions that tolerate many functional groups, leading to a broad substrate scope. This powerful ring-forming reaction very quickly assembles complex tetralins that are the formal products of the largely infeasible Diels-Alder cycloadditions of styrenes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164078 | PMC |
| http://dx.doi.org/10.1002/anie.202303228 | DOI Listing |
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