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Maternal apparent temperature during pregnancy on the risk of offspring asthma and wheezing: effect, critical window, and modifiers. | LitMetric

Maternal apparent temperature during pregnancy on the risk of offspring asthma and wheezing: effect, critical window, and modifiers.

Environ Sci Pollut Res Int

Department of Occupational and Environmental Health, School of Public Health, Cheeloo College of Medicine, Shandong University, 44 Wenhuaxi Road, Jinan, Shandong, 250012, People's Republic of China.

Published: May 2023

AI Article Synopsis

  • The study aimed to investigate how maternal temperature exposure (AT) during pregnancy affects the risk of childhood asthma and wheezing in young children aged 18 months to 3 years.
  • A cross-sectional study screened 12,384 vaccinated children, identifying 236 cases of asthma and wheezing, and further analyzed associations using advanced statistical models.
  • Results revealed significant links between cold exposure in the first trimester and both cold and heat exposure in the third trimester, especially affecting girls and children living near busy roads or with parents who have asthma.

Article Abstract

The objective of this study was to explore the impact of maternal AT during pregnancy on childhood asthma and wheezing, as well as the potential effect modifiers in this association. A cross-sectional study was implemented from December 2018 to March 2019 in Jinan to investigate the prevalence of childhood asthma and wheezing among aged 18 months to 3 years. Then, we conducted a case-control study based on population to explore the association between prenatal different AT exposure levels and childhood asthma and wheezing. The association was assessed by generalized additive models and logistic regression models, and stratified analyses were performed to explore potential effect modifiers. A total of 12,384 vaccinated children participated in screening for asthma and wheezing, 236 cases were screened, as well as 1445 controls were randomized. After adjusting for the covariates, childhood asthma and wheezing were significantly associated with cold exposure in the first trimester, with OR 1.731 (95% CI: 1.117-2.628), and cold exposure and heat exposure in the third trimester, with ORs 1.610 (95% CI: 1.030-2.473) and 2.039 (95% CI: 1.343-3.048). In the third trimester, enhanced impacts were found among girls, children whose distance of residence was close to the nearest main traffic road, and children whose parents have asthma. The study indicates that exposure to extreme AT during the first and third trimesters could increase the risk of childhood asthma and wheezing.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034250PMC
http://dx.doi.org/10.1007/s11356-023-26234-8DOI Listing

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