AI Article Synopsis
- - The total synthesis of the anti-tumor compound pongaflavone was achieved from 2,4-dihydroxyacetophenone in seven steps, yielding 16%.
- - Two analogues of pongaflavone, pongachromene and another trihydroxyflavone, were also synthesized with yields of 11% and 18%, respectively.
- - Preliminary tests on A549 cancer cells indicated varying anti-tumor activities, with pongachromene showing the most significant effect.
Article Abstract
The efficient total synthesis of anti-tumor natural product pongaflavone () was described starting from commercially available 2,4-dihydroxyacetophenone () via seven steps and in 16% overall yield. Its two natural analogues pongachromene () and 7,8-(2",2"-dimethylpyrano)-5,3',4'-trihydroxy-3-methoxyflavone () were also synthesized following the similar procedure with the yields of 11% and 18%, respectively. Their preliminary anti-tumor activities were evaluated by the inhibition effect on A549 cells. The result showed that this kind of natural products exhibited different levels of anti-tumor activity. Among them, pongachromene () displayed the best anti-tumor activity.
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| http://dx.doi.org/10.1080/10286020.2023.2193697 | DOI Listing |
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