This case study examines a patient undergoing an elective procedure who had a past medical history of Hemoglobin Louisville and presented with baseline oxygen saturation levels (SpO) in the 80s as measured by noninvasive pulse oximetry. It presents the anesthetic provided, a brief review of physiology, and a discussion pertaining to this particular genetic mutation. Understanding the physiological implications of these types of hemoglobinopathies and their anesthetic management is key to managing patients' care throughout the perioperative period. With new hemoglobin variants continuing to emerge, reviewing some of the rare hemoglobinopathies is prudent to support the anesthesia community in their assessment and care of patients who present with unexpectedly low SPO.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Hemoglobin Louisville: A Case Report.
AANA J
April 2023
is Assistant Professor at Georgetown University, Doctor of Nurse Anesthesia Practice Program, Washington, DC. Email:
This case study examines a patient undergoing an elective procedure who had a past medical history of Hemoglobin Louisville and presented with baseline oxygen saturation levels (SpO) in the 80s as measured by noninvasive pulse oximetry. It presents the anesthetic provided, a brief review of physiology, and a discussion pertaining to this particular genetic mutation. Understanding the physiological implications of these types of hemoglobinopathies and their anesthetic management is key to managing patients' care throughout the perioperative period.
View Article and Find Full Text PDFNight of Kentucky blues: the case of the hypoxic child in the sleep laboratory.
J Clin Sleep Med
October 2021
Department of Pediatrics, Division of Pediatric Pulmonary and Sleep Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Citation: Sleep-disordered breathing is an increasingly identified condition in the pediatric population, resulting in an increasing number of direct-to-lab referrals for polysomnography (PSG). We present a unique case of a pediatric patient who demonstrated continuous hypoxemia during PSG. A 6-year-old Black female presented for PSG via direct referral with obstructive sleep apnea as a concern.
View Article and Find Full Text PDFMisidentification of unstable, low oxygen affinity hemoglobin variant.
Clin Chim Acta
October 2020
Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA. Electronic address:
Background: We present a case of Hemoglobin (Hgb) Louisville in a 6-y old girl presenting with hypoxia and mild hemolytic anemia.
Methods: Hgb Louisville is a rare, unstable hemoglobin variant with low oxygen affinity, but initial workup of this case using widely-available hemoglobin fractionation methods was unable to differentiate this variant from normal hemoglobins.
Results: This resulted in a delayed diagnosis.
Low oxygen saturation and severe anemia in compound heterozygous Hb Louisville [β42(CD1)Phe→Leu] and Hb La Desirade [β129(H7)Ala→Val].
Hematology
March 2017
a Department of Pathology, Faculty of Medicine , Ramathibodi Hospital, Mahidol University, Bangkok , Thailand.
Objective: To investigate the cause(s) of a Thai male proband presenting low oxygen saturation by pulse oximetry (SpO) and severe anemia.
Methods: As Hb variant was suspected, Hb typing was determined by high-performance liquid chromatography and capillary electrophoresis, and subsequently Hb variant was identified by DNA sequencing. Complete blood counts were performed using automated blood cell counter and oxygen saturation was measured by pulse oximetry.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!