AI Article Synopsis
- * Recent interdisciplinary research has shed light on how flow affects various bacterial responses, including adhesion, movement, colonization, and gene expression.
- * The review focuses on four different bacterial species and outlines experimental methods to study their behavior in flow, highlighting that not all responses are due to shear forces and emphasizing flow-sensitive signaling in bacteria.
Article Abstract
Bacteria thrive in environments rich in fluid flow, such as the gastrointestinal tract, bloodstream, aquatic systems, and the urinary tract. Despite the importance of flow, how flow affects bacterial life is underappreciated. In recent years, the combination of approaches from biology, physics, and engineering has led to a deeper understanding of how bacteria interact with flow. Here, we highlight the wide range of bacterial responses to flow, including changes in surface adhesion, motility, surface colonization, quorum sensing, virulence factor production, and gene expression. To emphasize the diversity of flow responses, we focus our review on how flow affects four ecologically distinct bacterial species: Escherichia coli, Staphylococcus aureus, Caulobacter crescentus, and Pseudomonas aeruginosa. Additionally, we present experimental approaches to precisely study bacteria in flow, discuss how only some flow responses are triggered by shear force, and provide perspective on flow-sensitive bacterial signaling.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127660 | PMC |
| http://dx.doi.org/10.1128/jb.00400-22 | DOI Listing |
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