AI Article Synopsis
- The endoplasmic reticulum (ER) is a part of the cell that helps make and shape proteins that are secreted or embedded in cell membranes.
- Sometimes, proteins can get messed up and cause problems, which is called ER stress. This can happen for various reasons, like needing to make a lot of proteins quickly or genetic changes.
- A study found that a specific mutation (M98K) in a gene related to glaucoma makes certain eye cells more sensitive to ER stress, which can lead to cell death and involves a process that affects how the cell responds to stress.
Article Abstract
The endoplasmic reticulum (ER) is the organelle where the production and shaping of most secreted and transmembrane proteins happens. ER function is finely regulated to prevent accumulation of misfolded proteins generating ER stress. ER stress is common in both healthy and pathological situations due to multiple intrinsic and extrinsic factors including acute demand in protein synthesis, hypoxia or impaired protein folding caused by gene mutations. Sayyad et al. found that the M98K mutation of optineurin sensitizes glaucoma retinal ganglion cells to ER stress-induced cell death. This is associated with an autophagy-dependent elevation of ER stress sensor expression.
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| http://dx.doi.org/10.1111/febs.16774 | DOI Listing |
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