Quantifying relationships between cerebral blood flow (CBF), mitochondrial function (cytochrome c oxidase oxidation state), and metabolic rate of oxygen (CMRO) could provide useful insight into normal neurovascular coupling, as well as regulation of oxidative metabolism in neurological disorders. This paper uses a multimodal NIRS-MRI method to quantify these parameters in rodent brain and, in so doing, provides novel information on the regulation of oxygen metabolism by stimulating with hypercapnia or variations in oxygenation. Under hypercapnia, although oxygenation, oxidation state, and CBF increased, there was no increase in CMRO. Also, there was no correlation between CBF and CCO oxidation state. Conversely, changing oxygenation resulted in a strong correlation between the oxidation of CCO and CBF. This proves that the association between CBF and the redox state of CCO is not fixed and depends on the type of perturbation. Having a means to measure CBF and CCO oxidation state simultaneously will help understanding their contribution to intact neurovascular coupling and detecting abnormal cellular oxygen metabolism in many neurological disorders.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369142 | PMC |
| http://dx.doi.org/10.1177/0271678X231165842 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nanoscale Magnetic Ordering Dynamics in a High Curie Temperature Ferromagnet.
Nano Lett
January 2025
Materials Science and Technology Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, Tennessee 37831, United States.
Thermally driven transitions between ferromagnetic and paramagnetic phases are characterized by critical behavior with divergent susceptibilities, long-range correlations, and spin dynamics that can span kHz to GHz scales as the material approaches the critical temperature , but it has proven technically challenging to probe the relevant length and time scales with most conventional measurement techniques. In this study, we employ scanning nitrogen-vacancy center based magnetometry and relaxometry to reveal the critical behavior of a high- ferromagnetic oxide near its Curie temperature. Cluster analysis of the measured temperature-dependent nanoscale magnetic textures points to a 3D universality class with a correlation length that diverges near .
View Article and Find Full Text PDFCyclometalated Au(III) complexes with alkynylphosphine oxide ligands: synthesis and photophysical properties.
Dalton Trans
January 2025
Institute of Chemistry, St Petersburg University, Universitetskii pr. 26, 198504 St. Petersburg, Russia.
A series of cyclometalated Au(III) complexes [Au(C^N^C)(C-L-P(O)Ph)] with C^N^C = 2,6-diphenylpyridine and alkynylphosphine oxide ligands (L = no linker, Au1; phenyl, Au2; biphenyl, Au3; naphthyl, Au4; anthracenyl, Au5) were synthesized and fully characterized by spectroscopic methods and single crystal XRD analysis. The complexes obtained exhibit triplet (Au1-Au3) and dual (Au4, Au5) emissions in solution, in the solid phase and in the PMMA film, whose characteristics depend on the linker's nature of the alkynylphosphine oxide ligand. The description of electronic transitions responsible for energy absorption and emission in Au(III) complexes was made on the basis of a detailed analysis of the results of DFT calculations and has shown to involve ILCT, LLCT and MLCT transitions of singlet and triplet nature.
View Article and Find Full Text PDFAlkylazolation of Alkenes via Photocatalytic Radical Polar Crossover.
Org Lett
January 2025
Department of Chemistry, University of Hawai'i at Ma̅noa, Honolulu, Hawaii 96822, United States.
We present a photocatalytic method for alkylamination of alkenes, enabling efficient C-C and C-N bond formation to construct aza-heterocycles valuable in drug discovery. Using a radical-polar crossover pathway, electron-deficient alkenes are reduced to electrophilic radicals, which react with electron-rich alkenes to form nucleophilic radicals. Oxidation of these intermediates yields carbocations, which are trapped by aza-heteroarenes to afford alkylaminated products.
View Article and Find Full Text PDFRu(IV)-Ru(IV), Ru(III)-Ru(IV), and Ru(III)-Ru(III) complexes having a sulfato bridging ligand on the doubly oxido-/hydroxido-bridged core, and their crystallographic and electronic structures.
Dalton Trans
January 2025
Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan.
The Ru(IV,IV), Ru(III,IV), and Ru(III,III) complexes with the doubly oxido- and/or hydroxido-bridged diamond core {Ru(μ-O(H))}, bridged by an η:η:μ-type bidentate sulfato ligand, [{Ru(L)}(μ-O)(μ-OSO)] ( = 1: [III,IV]; = 2: [IV,IV]), [{Ru(L)}(μ-O)(μ-OH)(μ-OSO)] ([III,IV_1H]), and [{Ru(L)}(μ-OH)(μ-OSO)] ([III,III_2H]) (L = ethylbis(2-pyridylmethyl)amine), were synthesised as ClO-salts, and their crystal and electronic structures investigated. The corresponding hydrogencarbonato-bridged Ru(III,III) complex, [{Ru(L)}(μ-OH)(μ-OCOH)] ([III,III(HCO3)_2H]), was also prepared and its crystallographic and electronic structures compared to those of the sulfato-bridged system, [III,III_2H]. All the sulfato-bridged complexes isolated were confirmed in the Pourbaix diagram, wherein the redox potential was plotted as a function of pH.
View Article and Find Full Text PDFRadiolabeling of Siamenoside I with Carbon-14.
Org Lett
January 2025
The Coca-Cola Company, One Coca-Cola Plaza, Atlanta, Georgia 30313, United States.
The synthesis of radiolabeled [25-C]-siamenoside I following a synthetic route developed using unlabeled materials is disclosed. The synthesis features an early stage labeling of the mogrol's C25 an oxidative cleavage-reconstruction strategy and regioselective glycosylations directed by protecting group manipulations. This route provided access to adequate amounts of [25-C]-siamenoside I for ADME and PK studies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!