A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Priming mesenchymal stromal cells with neurotrophic factors boosts the neuro-regenerative potential of their secretome. | LitMetric

To explore the neuroprotective potential of the secretome (conditioned medium, CM) derived from neurotrophic factors-primed mesenchymal stromal cells (MSCs; primed CM) using an endoplasmic reticulum (ER) stress-induced model system. Establishment of ER-stressed model, immunofluorescence microscopy, real-time PCR, western blot. Exposure of ER-stressed Neuro-2a cells to the primed-CM significantly restored the neurite outgrowth parameters and improved the expression of neuronal markers like and in them compared with the naive CM. Primed CM also suppressed the induction of apoptotic markers and , inflammatory markers and NF-κB, and stress kinases such as p38 and SAPK/JNK in the stress-induced cells. The secretome from primed MSCs significantly restored ER stress-induced loss of neuro-regenesis.

Download full-text PDF

Source
http://dx.doi.org/10.2217/rme-2022-0201DOI Listing

Publication Analysis

Top Keywords

mesenchymal stromal
8
stromal cells
8
potential secretome
8
priming mesenchymal
4
cells
4
cells neurotrophic
4
neurotrophic factors
4
factors boosts
4
boosts neuro-regenerative
4
neuro-regenerative potential
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!