Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027001 | PMC |
http://dx.doi.org/10.3389/fcimb.2023.1170834 | DOI Listing |
Clin Epigenetics
December 2024
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Diagn Microbiol Infect Dis
December 2024
Department of Molecular Epidemiology, National Institute of Malaria Research, Sector-8, Dwarka, Delhi 110077, India. Electronic address:
Microsatellites, or simple sequence repeats (SSRs), are short tandemly repeated DNA sequences widely dispersed throughout the genome. Their high variability, co-dominant inheritance, and ease of detection make them valuable genetic markers, frequently used to study genetic diversity, population structure, and evolutionary processes. In the context of malaria research, particularly with Plasmodium falciparum (P.
View Article and Find Full Text PDFJ Ethnopharmacol
December 2024
Department of Pathogenic Biology and Immunology, College of Integrated Chinese and Western Medicine (College of Life Science), Anhui University of Chinese Medicine, Hefei, China; Institute of Integrated Traditional Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China. Electronic address:
Ethnopharmacological Relevance: Vulvovaginal candidiasis (VVC) is a relatively common fungal infectious disease in the female reproductive tract. The pathogenesis of VVC not only involves Candida albicans (C. albicans) infection, but also the improper immune response of the vaginal mucosal immune system to the fungus.
View Article and Find Full Text PDFTrends Biochem Sci
December 2024
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia. Electronic address:
Necroptosis is a mode of programmed cell death executed by the mixed lineage kinase domain-like (MLKL) pseudokinase following its activation by the upstream receptor-interacting protein kinase-3 (RIPK3), subsequent to activation of death, Toll-like, and pathogen receptors. The pathway originates in innate immunity, although interest has surged in therapeutically targeting necroptosis owing to its dysregulation in inflammatory diseases. Here, we explore how protein conformation and higher order assembly of the pathway effectors - Z-DNA-binding protein-1 (ZBP1), RIPK1, RIPK3, and MLKL - can be modulated by post-translational modifications, such as phosphorylation, ubiquitylation, and lipidation, and intermolecular interactions to tune activities and modulate necroptotic signaling flux.
View Article and Find Full Text PDFCurr Opin Biotechnol
December 2024
Department of Biological Systems and Engineering, Lawrence Berkeley National Laboratory 1 Cyclotron Rd, Berkeley, CA 94702. Electronic address:
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!