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[Electroencephalogram Features of Anti-N-Methyl-D-Aspartate Receptor Encephalitis and Their Value for Clinical Assessment]. | LitMetric

AI Article Synopsis

  • The study focused on evaluating EEG features in patients with anti-NMDA receptor encephalitis and how these correlate with clinical conditions, like the severity of the disease and prognosis.
  • Out of 52 patients examined, most demonstrated abnormal EEG readings, and the presence of δ brush was noted in 12% of cases; those with more severe EEG abnormalities were more likely to require ICU care.
  • The findings suggest that greater EEG background slowing and the presence of δ brush are associated with worse outcomes, higher levels of antibodies, and the need for more aggressive treatment in patients.

Article Abstract

Objective: To analyze the electroencephalogram (EEG) features of anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) and to study the clinical assessment value of the degree of EEG background slowing and the presence of δ brush.

Methods: We enrolled 52 patients with anti-NMDARE and collected their clinical data, including age, sex, form of disease onset, status of tumor comorbidity, auxiliary examination findings (cerebrospinal fluid [CSF] anti-methyl-D-aspartate receptor antibody titers, magnetic resonance imaging [MRI] reports, and EEG results), treatment status, and follow-up after discharge. The degree of EEG background abnormality and the presence of δ brush in the EEG of patients with different clinical features were analyzed.

Results: Among the 52 patients, 7 (14%) had normal EEG, and 45 (87%), abnormal EEG, including 25 (48%) with mild abnormalities, 11 (21%) with moderate abnormalities, and 9 (17%) with severe abnormalities. δ brush was seen in 6 (12%) patients. At the time of EEG, 32 (62%) patients were in the mild condition group and 20 (38%) patients were in the severe condition group. After 1 year of follow-up, there were 45 (86%) patients in the good prognosis group and 7 (14%) patients in the poor prognosis group. The exacerbation of EEG background abnormalities and the presence of δ brush were indications for an increase in the proportion of patients who were in severe condition, who needed ICU admission, and who had poor prognosis ( <0.01). The worse the EEG background abnormalities, the higher the proportion of CSF antibody titers>1∶10 ( =0.035), and the higher the proportion of patients initiating second-line immunotherapy ( =0.008). The δ brush was seen a higher proportion in patients with comorbid tumors ( =0.012). The probability of δ brush presence was higher in the first-time diagnosis cases than that in recurrent cases ( =0.023).

Conclusions: The degree of EEG slowing and the presence of δ brush have shown consistent performance in assessing patients' condition and predicting prognosis. The slower the EEG, the more severe the disease, and the worse the prognosis. The presence of δ brush indicates severe disease and poor prognosis. EEG slowing is correlated with the immune status of patients with anti-NMDARE. The slower the EEG, the more severe the immune abnormalities. In clinical practice, patient EEG should be under dynamic monitoring in order to evaluate the effect of immunotherapy. If EEG slowing is not improved, enhanced immunotherapy should be considered as early as possible. The δ brush is seen at a higher proportion in patients with comorbid tumors. Therefore, active efforts should be made to screen for tumors when δ brush is present.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409173PMC
http://dx.doi.org/10.12182/20230360502DOI Listing

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