AI Article Synopsis
- - Heart failure (HF) is a growing health issue linked to high mortality, and GDF15, a stress response cytokine, may indicate poor outcomes in cardiovascular diseases, though its role in Japanese HF patients is not well-established.
- - In a study of 1,201 HF patients, researchers tracked serum GDF15 and BNP levels over an average of 1,309 days, finding that higher GDF15 levels correlated with increased risk of HF-related events and deaths.
- - The study concluded that GDF15 levels are valuable in assessing HF severity and predicting clinical outcomes, making it a potential tool for monitoring patient health in those with heart failure.
Article Abstract
Background: Heart failure (HF) is an increasing health problem associated with a high mortality rate. Growth differentiation factor (GDF) 15, a stress response cytokine belonging to the transforming growth factor-β superfamily, is associated with poor clinical outcomes in a broad spectrum of cardiovascular diseases. However, the prognostic usefulness of GDF15 in Japanese patients with HF remains unclear.
Methods and results: We measured serum concentrations of GDF15 and B-type natriuretic peptide (BNP) in 1,201 patients with HF. All patients were prospectively followed for a median period of 1,309 days. In all, 319 HF-related events and 187 all-cause deaths occurred during the follow-up period. Kaplan-Meier analysis demonstrated that, among GDF15 tertiles, the highest tertile group had the greatest risk of HF-related events and all-cause mortality. Multivariate Cox proportional hazard regression analysis demonstrated that the serum GDF15 concentration was an independent predictor of HF-related events and all-cause deaths after adjusting for confounding risk factors. Serum GDF15 improved the prediction capacity for all-cause deaths and HF-related events with a significant net reclassification index and integrated discrimination improvement. Subgroup analysis in patients with HF with preserved ejection fraction also showed the prognostic usefulness of GDF15.
Conclusions: Serum GDF15 concentrations were associated with HF severity and clinical outcomes, indicating that GDF15 could provide additional clinical information to track the health status of patients with HF.
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| http://dx.doi.org/10.1253/circj.CJ-23-0088 | DOI Listing |
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