Seven new 18-residue peptaibols, trichorzins A-G (-), were isolated from the sponge-derived fungus sp. GXIMD 01001. Their structures and configurations were characterized by a comprehensive interpretation of the NMR spectroscopic data, MS/MS fragmentation, Marfey's method, and ECD analysis. The general sequences of trichorzins A-G are as follows: Ac-Aib-Ala/Ser-Ala-Aib/Iva-Iva-Gln-Aib/Iva-Val/-Ile-Aib-Gly-Leu-Aib-Pro-Leu-Aib-Aib-Gln-Trpol/Pheol. The obtained compounds were assessed for their potential antiproliferative and antimicrobial activities. All obtained compounds did not show potent antibacterial activity but exhibited significant cytotoxicity, with the lowest IC values at 0.46-4.7 μM against four human carcinoma cell lines.
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Article Synopsis
- * The structural configurations for the new peptaibols were determined using techniques like nuclear magnetic resonance (NMR) and high-resolution mass spectrometry, while their absolute configurations were assessed using Marfey's method.
- * All 18-residue peptaibols showed moderate antibacterial activity against Staphylococcus aureus, with MIC values between 8-32 μg·mL, while one 14-res
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