Zeroing in on the right drug regimen requires a look at an agent's clinical benefits, tolerability profile, and risk of drug interactions, as well as the patient's comorbidities.
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Protein prenylation in mechanotransduction: implications for disease and therapy.
Trends Pharmacol Sci
January 2025
Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. Electronic address:
The process by which cells translate external mechanical cues into intracellular biochemical signals involves intricate mechanisms that remain unclear. In recent years, research into post-translational modifications (PTMs) has offered valuable insights into this field, spotlighting protein prenylation as a crucial mechanism in cellular mechanotransduction and various human diseases. Protein prenylation, which involves the covalent attachment of isoprenoid groups to specific substrate proteins, profoundly affects the functions of key mechanotransduction proteins such as Rho, Ras, and lamins.
View Article and Find Full Text PDFEffectiveness of Multilevel Implementation Strategies for Autism Interventions: Outcomes of Two Linked Implementation Trials.
J Am Acad Child Adolesc Psychiatry
January 2025
University of California, Davis; MIND Institute.
Objective: This study tests the effectiveness of leader and provider-level implementation strategies to implement evidence-based interventions (EBIs) in two of the service systems caring for autistic children. The TEAMS Leadership Institute (TLI) targets implementation leadership and climate, and TEAMS Individualized Provider Strategy (TIPS) targets provider motivation and engagement.
Method: A cluster randomized hybrid type 3 implementation-effectiveness trial tested the effects of the implementations strategies when paired with AIM HI (An Individualized Mental Health Intervention for Autism) in mental health programs (Study 1) and CPRT (Classroom Pivotal Response Teaching) in classrooms (Study 2).
Comparison of clinical outcomes in patients with refractory ascites treated with either TIPS, tunneled peritoneal catheter, or ascites pump.
Hepatol Commun
February 2025
Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
Background: Refractory ascites (RA) remains a serious complication in patients with cirrhosis. Currently, the insertion of a TIPS is considered the standard of care in these patients. To achieve symptom control in those with TIPS contraindications, tunneled peritoneal catheters (PeCa) or ascites pumps were introduced.
View Article and Find Full Text PDFLow-Intensity Online Intervention for Mental Distress Among Help-Seeking Young People in Hong Kong: A Randomized Clinical Trial.
JAMA Netw Open
January 2025
Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
Importance: Mental health issues among young people are increasingly concerning. Conventional psychological interventions face challenges, including limited staffing, time commitment, and low completion rates.
Objective: To evaluate the effect of a low-intensity online intervention on young people in Hong Kong experiencing moderate or greater mental distress.
Denial as an ethical problem: the example of ICU triage in the context of the COVID-19 pandemic.
Asian J Med Humanit
January 2024
Faculté de Medicine, Université de Montréal, Montréal, Québec, Canada.
Objectives: The overall goal of this article is to show that denial is one of the greatest obstacles to good practical judgment and is therefore a major problem in clinical ethics by examining its cognitive structure and the challenges it poses for clinical ethics consultation and intervention. In addition to clinical examples, excerpts of verbatim from citizen forums on triage protocols will be used to illustrate the manifestations of denial in citizens when faced with difficult choices.
Case Presentation: The initial waves of the pandemic and the alarming resurgence of cases with the emergence of highly transmissible variants have created increased pressure on many healthcare systems around the world.
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