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| http://dx.doi.org/10.1289/EHP12772 | DOI Listing |
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Octahedral small virus-like particles of dengue virus type 2.
J Virol
December 2024
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
Unlabelled: Flavivirus envelope (E) and precursor M (prM) proteins, when ectopically expressed, assemble into empty, virus-like particles (VLPs). Cleavage of prM to M and loss of the pr fragment converts the VLPs from immature to mature particles, mimicking a similar maturation of authentic virions. Most of the VLPs obtained by prM-E expression are smaller than virions; early, low-resolution cryo-EM studies suggested a simple, 60-subunit, icosahedral organization.
View Article and Find Full Text PDFPan-serotype dengue virus inhibitor JNJ-A07 targets NS4A-2K-NS4B interaction with NS2B/NS3 and blocks replication organelle formation.
Nat Commun
July 2024
Heidelberg University, Medical Faculty Heidelberg, Department of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research, Heidelberg, Germany.
Article Synopsis
- Dengue fever poses a major health and economic challenge in (sub)tropical regions, with no antiviral treatments currently available.
- JNJ-A07 has been shown to be effective against various dengue virus genotypes by targeting the viral non-structural protein 4B (NS4B) and disrupting important interactions needed for viral replication.
- This research clarifies how JNJ-A07 and a similar compound, NITD-688, inhibit the formation of vesicle packets crucial for dengue virus RNA replication, offering new insights into potential antiviral strategies.
In silico design of peptide inhibitors for Dengue virus to treat Dengue virus-associated infections.
Sci Rep
June 2024
Centre for Applied Mathematics and Bioinformatics, Gulf University for Science and Technology, Hawally, Kuwait.
Dengue virus is a single positive-strand RNA virus that is composed of three structural proteins including capsid, envelope, and precursor membrane while seven non-structural proteins (NS1, NS2A, NS2B, NS3A, NS3B, NS4, and NS5). Dengue is a viral infection caused by the dengue virus (DENV). DENV infections are asymptomatic or produce only mild illness.
View Article and Find Full Text PDFTriple Trouble.
J Assoc Physicians India
March 2024
Professor, Department of Medicine, Bharati Vidyapeeth Medical College, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra, India, Corresponding Author.
We present a case of a 24-year-old female recently diagnosed with acute leukemia who came with complaints of fever for 14 days, progressive lower limb weakness, and multiple episodes of vomiting in the last 1 day. In nerve conduction studies, a diagnosis of Guillain-Barré syndrome (GBS) was established. Fever with thrombocytopenia workup revealed a positive dengue nonstructural protein 1 (NS1) and immunoglobulin M (IgM) report.
View Article and Find Full Text PDFDevelopment of a tetravalent subunit vaccine against dengue virus through a vaccinomics approach.
Front Immunol
December 2023
Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Punjab, Pakistan.
Dengue virus infection (DVI) is a mosquito-borne disease that can lead to serious morbidity and mortality. Dengue fever (DF) is a major public health concern that affects approximately 3.9 billion people each year globally.
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