An expeditious and novel nickel-catalyzed selective arylhydroxylation of unactivated alkenes with arylboronic acids was developed. This protocol is compatible with β,γ- and γ,δ-alkene amides, including traditionally challenging internal alkenes, to provide important β-arylethylalcohol scaffolds. The free hydroxyl group in the final product could be smoothly further transformed into other functional groups. Control experiments indicated that the oxygen atom of the hydroxyl group in the product is derived from the oxygen in the air.
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- The study presents a nickel-catalyzed method for converting nitriles to alcohols using molecular hydrogen, involving a sequence of reactions.
- This method is efficient for different types of nitriles and can be applied to complex drug molecules, producing alcohols that are crucial in many fields such as organic synthesis and energy technology.
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