AI Article Synopsis
- Neurons can release multiple neurotransmitters at the same time, challenging the old view that each nerve only uses one transmitter.
- Acetylcholine influences norepinephrine release in noradrenergic neurons, indicating a complex interaction at the autonomic junctions.
- This research expands on Dale's principle by showing that neurotransmission is not limited to norepinephrine, highlighting the roles of other substances like purinergic and peptidergic signals.
Article Abstract
It is now scientificallyaccepted that neurons have the ability to release multiple transmitter substances simultaneously, yet, cotransmission's functionality is still limited to the scientific community. Acetylcholine is released by the noradrenergic neurons, and then the acetylcholine works prejunctionally in the promotion of the noradrenaline release. This hypothesis significantly challenged the previous idea of autonomic transmission as being a simple process that had a single transmitter. Norepinephrine was thought to be the single transmitter at the sympathetic neurovascular junction according to "Dale's principle". However, more evidence of the involvement of other neurotransmitters has been shown by many researchers in conjunction with Dale's principle and established terms such as adrenergic, purinergic, and peptidergic nerves. With the discovery of cotransmission, we now understand the existence of more than one neurotransmitter at a sympathetic neurovascular junction.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025427 | PMC |
| http://dx.doi.org/10.7759/cureus.35124 | DOI Listing |
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