AI Article Synopsis
- * Key genes studied include WNT16, FAM3C, ING3, CPED1, and TSPAN12, with strong evidence from mouse studies showing WNT16's essential role in maintaining bone mass and strength.
- * Recent research in zebrafish reveals WNT16's dual role in shaping both bone and muscle, raising new questions about how its influence may affect BMD and fracture risk.
Article Abstract
Purpose Of Review: Chromosome region 7q31.31, also known as the CPED1-WNT16 locus, is robustly associated with BMD and fracture risk. The aim of the review is to highlight experimental studies examining the function of genes at the CPED1-WNT16 locus.
Recent Findings: Genes that reside at the CPED1-WNT16 locus include WNT16, FAM3C, ING3, CPED1, and TSPAN12. Experimental studies in mice strongly support the notion that Wnt16 is necessary for bone mass and strength. In addition, roles for Fam3c and Ing3 in regulating bone morphology in vivo and/or osteoblast differentiation in vitro have been identified. Finally, a role for wnt16 in dually influencing bone and muscle morphogenesis in zebrafish has recently been discovered, which has brought forth new questions related to whether the influence of WNT16 in muscle may conspire with its influence in bone to alter BMD and fracture risk.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202127 | PMC |
| http://dx.doi.org/10.1007/s11914-023-00783-w | DOI Listing |
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