Context: Saturated fats found in diets known as high-fat, cafeteria, or Western diets appear to have a negative effect on bone structure; however, few studies have focused on investigating this association, and the data available in the literature remain controversial.
Objective: The aim of the current review was to investigate the effects of a high-fat dietary intake on the bone structure of Wistar rats.
Data Sources: A search for articles was carried out in the Pubmed/MEDLINE, Web of Science, Embase, and Scopus databases.
Data Extraction: In total, 447 articles were found in the initial search; 5 articles were included in the systematic review, after application of the exclusion criteria.
Data Analysis: The review was guided by the PICOS strategy and based on the PRISMA protocol for animal reviews.
Conclusion: High-fat diets appear to affect bone structure of Wistar rats. Diet composition and exposure time are the factors determining the strength of the effect.
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| http://dx.doi.org/10.1093/nutrit/nuad024 | DOI Listing |
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