AI Article Synopsis

  • - The effectiveness and lifespan of medical implants depend on the body's immune response, which can either cause inflammation or promote healing.
  • - Researchers studied a collagen polymeric scaffold made from oligomeric collagen in rats, finding it showed no negative immune reactions or inflammation for over 60 days, unlike commercial products.
  • - Gene analysis indicated that the Oligomer scaffolds promote a healing response by increasing immune tolerance and supporting tissue regeneration, rather than causing inflammation.

Article Abstract

The efficacy and longevity of medical implants and devices is largely determined by the host immune response, which extends along a continuum from pro-inflammatory/pro-fibrotic to anti-inflammatory/pro-regenerative. Using a rat subcutaneous implantation model, along with histological and transcriptomics analyses, we characterized the tissue response to a collagen polymeric scaffold fabricated from polymerizable type I oligomeric collagen (Oligomer) in comparison to commercial synthetic and collagen-based products. In contrast to commercial biomaterials, no evidence of an immune-mediated foreign body reaction, fibrosis, or bioresorption was observed with Oligomer scaffolds for beyond 60 days. Oligomer scaffolds were noninflammatory, eliciting minimal innate inflammation and immune cell accumulation similar to sham surgical controls. Genes associated with Th2 and regulatory T cells were instead upregulated, implying a novel pathway to immune tolerance and regenerative remodeling for biomaterials.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152923PMC
http://dx.doi.org/10.1039/d3bm00091eDOI Listing

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