Xanchryones I-N, Six Unusual Phloroglucinol-Amino Acid Hybrids from the Leaves of Xanthostemon chrysanthus.

Chem Biodivers

Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China.

Published: April 2023

Six new phloroglucinol derivatives, xanchryones I-N (1-6), were isolated from the leaves of Xanthostemon chrysanthus. Compounds 1-6 are unusual phloroglucinol-amino acid hybrids constructed through C -N and O-C ' bonds forming a peculiar oxazole ring. The structures and absolute configurations of compounds 1-6 were determined by MS, NMR, and single-crystal X-ray diffraction. Moreover, the anti-inflammatory and antibacterial activities of these compounds were evaluated.

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http://dx.doi.org/10.1002/cbdv.202300234DOI Listing

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Xanchryones I-N, Six Unusual Phloroglucinol-Amino Acid Hybrids from the Leaves of Xanthostemon chrysanthus.

Chem Biodivers

April 2023

Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China.

Six new phloroglucinol derivatives, xanchryones I-N (1-6), were isolated from the leaves of Xanthostemon chrysanthus. Compounds 1-6 are unusual phloroglucinol-amino acid hybrids constructed through C -N and O-C ' bonds forming a peculiar oxazole ring. The structures and absolute configurations of compounds 1-6 were determined by MS, NMR, and single-crystal X-ray diffraction.

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