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14-3-3 promotes sarcolemmal expression of cardiac Ca1.2 and nucleates isoproterenol-triggered channel superclustering.
Proc Natl Acad Sci U S A
February 2025
Department of Physiology and Membrane Biology, University of California Davis, Davis, CA 95616.
The L-type Ca channel (Ca1.2) is essential for cardiac excitation-contraction coupling. To contribute to the inward Ca flux that drives Ca-induced-Ca-release, Ca1.
View Article and Find Full Text PDFModeling Pathways by which the Caregiver TLC Psychoeducational Program Impacts Psychological Health of Caregivers.
Gerontologist
January 2025
Photozig, Inc., Moffett Field, CA, USA.
Background And Objectives: The study seeks to elucidate the pathways by which the Caregiver TLC psycho-educational program impacts the psychological health of caregivers by examining the degree to which changes in self-efficacy, personal gains, and emotional support mediate the changes on perceived depression, anxiety and burden.
Research Design And Methods: Using pre-post data from the Caregiver TLC randomized controlled trial (n = 81) for each outcome and mediator pair, a series of multiple regression models were executed to test the degree to which the program's total effects on changes in depression, burden and anxiety from baseline to post-intervention are due to changes in each mediator variable from pre- and post-intervention assessments. Caregivers were primarily female (85%), White (62 %), Black (38%), with a median age of 62 and household income of $75,000+.
Molecular Drivers of Aging in Biomolecular Condensates: Desolvation, Rigidification, and Sticker Lifetimes.
PRX Life
June 2024
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
Biomolecular condensates are dynamic intracellular entities defined by their sequence- and composition-encoded material properties. During aging, these properties can change dramatically, potentially leading to pathological solidlike states, the mechanisms of which remain poorly understood. Recent experiments reveal that the aging of condensates involves a complex interplay of solvent depletion, strengthening of sticker links, and the formation of rigid structural segments such as beta fibrils.
View Article and Find Full Text PDFThe Meaning of Ageing and the Educational Intervention "Good Life in Old Age": An Ethnographic Study Reflecting the Perspective of Older Adults with Mild Intellectual Disability.
Int J Environ Res Public Health
January 2025
Department of Health Sciences, Faculty of Medicine, Lund University, P.O. Box 117, SE-221 00 Lund, Sweden.
Older adults with intellectual disabilities are not adequately prepared for ageing and show anxiety and uncertainty regarding the future. Therefore, the two-year educational intervention "Good Life in Old Age" was implemented to improve their understanding of ageing and enhance their well-being. This study aimed to explore the meaning of ageing during and after the intervention from the perspective of older adults with mild intellectual disability.
View Article and Find Full Text PDFDiurnal timing of physical activity in relation to obesity and diabetes in the German National Cohort (NAKO).
Int J Obes (Lond)
January 2025
Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
Background: Physical activity supports weight regulation and metabolic health, but its timing in relation to obesity and diabetes remains unclear. We aimed to assess the diurnal timing of physical activity and its association with obesity and diabetes.
Methods: We cross-sectionally analyzed hip-worn accelerometry data from 61,116 participants aged 20-75 in the German National Cohort between 2015 and 2019.
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