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Comparison of Metastatic Patterns Among Neuroendocrine Tumors, Neuroendocrine Carcinomas, and Nonneuroendocrine Carcinomas of Various Primary Organs. | LitMetric

AI Article Synopsis

  • Neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) are both classified as neuroendocrine neoplasms (NENs) and were compared to non-neuroendocrine neoplasms (non-NENs) to identify differences in their metastatic patterns.
  • Analysis of data from over 45,000 patients revealed that NETs and NECs generally had similar metastatic behavior, with NENs exhibiting different organ-specific metastasis rates compared to non-NENs, particularly a higher rate to the liver.
  • Unique site-specific differences emerged, with certain non-NENs influencing metastasis rates more than NENs, suggesting that the multigene program responsible for neuro

Article Abstract

Background: Both neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) exhibit neuroendocrine differentiation and are classified as neuroendocrine neoplasms (NENs). NECs and nonneuroendocrine neoplasms (non-NENs), such as adenocarcinoma, have similar mutational profiles. The purpose of this study was to identify differences in metastatic patterns and to identify the key factor causing these differences by simultaneously comparing the metastatic patterns of NETs, NECs and non-NENs from various primary organs.

Methods: We retrieved data for 4,223 patients with NENs and 41,637 patients with non-NENs arising at various primary sites from an institutional database and then compared NET, NEC, and non-NEN metastatic patterns.

Results: NETs and NECs showed generally similar metastatic patterns. Most NEN patients had a higher liver organotrophic metastasis rate, lower lung organotrophic metastasis rate, and lower pleural/peritoneal organotrophic metastasis rate than non-NEN patients. Some differences were characteristics of specific organs. Some of these site-specific differences were not caused by NENs but by non-NENs, including a higher bone organotrophic metastasis rate for medullary thyroid carcinoma and a lower bone organotrophic metastasis rate for pulmonary NEN. Other differences were probably caused by NENs, including a higher bone organotrophic metastasis rate for colorectal NETs. Uterine cervical NEC showed unique patterns of metastasis compared to NEN from other sites.

Conclusion: Significant differences between the metastatic patterns of NENs and non-NENs were detected. The multigene program that causes neuroendocrine differentiation might be associated with organotropic metastasis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027546PMC
http://dx.doi.org/10.3346/jkms.2023.38.e85DOI Listing

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