Pilomatricoma, formerly known as calcifying epithelioma of Malherbe, is a rare, benign, annexic skin tumor developed from the cells of the pilar matrix. The cure without recurrence is the rule after complete surgical excision. Clinical diagnosis is challenging. Actually, differential diagnosis include malignant pilomatricoma or trichomatrical carcinoma with significant aggressive potential. However, the diagnosis of pilomatricoma must remain clinical and be confirmed histologically. We report the rare case of a pilomatricoma, in an unusual location in the thigh.
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http://dx.doi.org/10.11604/pamj.2022.43.208.34861 | DOI Listing |
Skinmed
January 2025
Dermatology Department, Miguel Servet Hospital, IIS Aragon, Zaragoza University, Zaragoza, Spain.
A 63-year-old man, with no past medical history, presented with an asymptomatic, progressively evolving polypoid lesion for 2 years in the left ciliary region. Physical examination revealed an exophytic tumor lesion of firm consistency and lobulated surface, with regular and well-defined borders. It measured 2 cm in diameter, and had a brownish-violet coloration with whitish areas (Figure 1).
View Article and Find Full Text PDFInt J Dermatol
December 2024
Division of Dermatology, Baylor University Medical Center, Dallas, Texas, USA.
Virchows Arch
November 2024
Department of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, Tours, France.
Recurrent mutations in the CTNNB1 or APC genes leading to the activation of the Wnt/betacatenin pathway are observed in adnexal tumors with matrical differentiation. While most pilomatricomas arise sporadically and harbor CTNNB1 mutations, cutaneous hybrid cysts combining epidermal and matrical differentiations have been mostly reported in a context of the familial adenomatosis polyposis/Gardner's syndrome related to germinal mutations of APC. The objective of this study is to understand the pathogenesis of hybrid cysts combining epidermal and matrical differentiations.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
December 2024
Department of ENT and Head-Neck Surgery, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India.
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